1-(2,6-Difluorophenyl)ethanone

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Names

[ CAS No. ]:
13670-99-0

[ Name ]:
1-(2,6-Difluorophenyl)ethanone

[Synonym ]:
2,6-Difluoroacetophenone
2′,6′-Difluoroacetophenone
EINECS 237-151-9
2’,6’-Difluoroacetophenone
2',6'-Difluoroacetophenone
MFCD00000328
1-(2,6-Difluorophenyl)ethanone
2-Acetyl-1,3-difluorobenzene
Ethanone, 1-(2,6-difluorophenyl)-
2‘,6‘-Difluoroacetophenone
1-(2,6-Difluorophenyl)ethan-1-one

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
178.6±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H6F2O

[ Molecular Weight ]:
156.129

[ Flash Point ]:
76.7±0.0 °C

[ Exact Mass ]:
156.038666

[ PSA ]:
17.07000

[ LogP ]:
0.96

[ Vapour Pressure ]:
1.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.473

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,6-Difluorobenzoyl chloride
  • Diethyl malonate
  • Potassium monoethyl malonate
  • 2,6-Difluorobenzonitrile
  • Acetyl chloride
  • 1,3-difluoro-2-trimethylsilylbenzene
  • METHYLLITHIUM
  • 1,3-Difluorobenzene
  • Ethanoic anhydride
  • (2,6-difluorophenyl)lithium

DownStream

  • 1-(2,6-Difluorophenyl)ethanol
  • 2-Bromo-1-(2,6-difluorophenyl)ethanone
  • 4-FLUORO-3-METHYL-1H-INDAZOLE
  • 3-(2,6-Difluorophenyl)-3-oxopropanenitrile

Articles

Synthesis of 2-aminoquinazolines from ortho-fluoroketones. Hynes JB, et al.

J. Heterocycl. Chem. 32(4) , 1185-87, (1995)

Ruthenium-catalyzed arylation of fluorinated aromatic ketones via< i> ortho</i>-selective carbon-fluorine bond cleavage. Kawamoto K, et al.

Tetrahedron Lett. 52(44) , 5888-5890, (2011)


More Articles

Related Compounds

  • 2-Bromo-1-(2,6-difluorophenyl)ethanone
  • 2-Chloro-1-(2,6-difluorophenyl)ethanone
  • (Z)-1-(2,6-DIFLUOROPHENYL)ETHANONE OXIME
  • 1-[(2,6-difluorophenyl)methyl]-2-phenylbenzimidazole
  • 1-[(2,6-difluorophenyl)methyl]-3-(4-ethyl-1,3-thiazol-2-yl)thiourea
  • 1-(2,6-difluorophenyl)-3H-indol-2-one
  • N-(3,4-dichlorophenyl)-2,5-diethoxy-4-methylbenzene-1-sulfonamide
  • 1-(4-bromo-2,5-dimethylbenzenesulfonyl)-5-methyl-1H-1,2,3-benzotriazole
  • 2-Chlorophenyl 5-bromo-2,4-dimethylbenzene-1-sulfonate
  • 2-methoxy-4-methyl-N-(4-methylphenyl)-5-(propan-2-yl)benzene-1-sulfonamide
  • 1-(2,4-Dibromo-5-methylbenzenesulfonyl)-4-(4-methylphenyl)piperazine
  • 1-[4-Methyl-5-(propan-2-yl)-2-propoxybenzenesulfonyl]-4-(4-methylphenyl)piperazine
  • N-(2,5-dichlorophenyl)-5-ethyl-2-methoxybenzene-1-sulfonamide
  • 2,4-Dimethylphenyl 5-bromo-2,4-dimethylbenzene-1-sulfonate
  • 2-Acetamidophenyl 2-bromo-4,5-dichlorobenzene-1-sulfonate
  • 5-bromo-2,4-dimethyl-N-(1H-1,2,4-triazol-3-yl)benzene-1-sulfonamide
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