TDCPP
Suppliers
Names
[ CAS No. ]:
13674-87-8
[ Name ]:
TDCPP
[Synonym ]:
Phosphoric Acid Tris(1,3-dichloro-2-propyl) Ester
Tris(1,3-dichloro-2-propanyl) phosphate
Tri(β,β'-dichloroisopropyl) phosphate
MFCD00083121
Tris(1,3-dichloropropan-2-yl) phosphate
TDCPP
Tris(1,3-dichloroisopropyl) phosphate
EINECS 237-159-2
Tris(1,3-dichloro-2-propyl) phosphate
1,3-Dichloro-2-propanol phosphate (3:1)
Phosphoric acid, tris(1,3-dichloro-2-propyl) ester
G1Y1GOPO&OY1G1G&OY1G1G
1,3-Dichloro-2-propanol phosphate (Phosphoric acid tris(1,3-dichloro-2-propyl ester)
Tris(2,2′-dichloroisopropyl) phosphate
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
457.4±40.0 °C at 760 mmHg
[ Melting Point ]:
-64°C
[ Molecular Formula ]:
C9H15Cl6O4P
[ Molecular Weight ]:
430.905
[ Flash Point ]:
377.7±35.0 °C
[ Exact Mass ]:
427.883911
[ PSA ]:
54.57000
[ LogP ]:
1.79
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.497
[ Water Solubility ]:
<0.1 g/100 mL at 24 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UB1473000
- CAS REGISTRY NUMBER :
- 13674-87-8
- BEILSTEIN REFERENCE NO. :
- 1715458
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C9-H15-Cl6-O4-P
- MOLECULAR WEIGHT :
- 430.91
- WISWESSER LINE NOTATION :
- G1Y1GOPO&OY1G1GOY1G1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1850 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >23700 mg/kg
- TOXIC EFFECTS :
- Behavioral - irritability Gastrointestinal - hypermotility, diarrhea Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15561 mg/kg/13W-C
- TOXIC EFFECTS :
- Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors Blood - pigmented or nucleated red blood cells
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 16800 mg/kg/12W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 24 gm/kg/5D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 58400 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3600 mg/kg
- SEX/DURATION :
- female 7-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3600 mg/kg
- SEX/DURATION :
- female 7-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 20 umol/L
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 56,20,1985 *** REVIEWS *** TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 17,101,1980
Safety Information
[ Symbol ]:
GHS08, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H351-H411
[ Precautionary Statements ]:
P273-P281
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn: Harmful;N: Dangerous for the environment;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S26-S36/37/39-S61
[ RIDADR ]:
UN 3082 9/PG 3
[ RTECS ]:
UB1473000
[ HS Code ]:
2919900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2919900090
[ Summary ]:
2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
Articles
Appl. Environ. Microbiol. 80(18) , 5866-73, (2014)
Phosphotriesterases catalyze the first step of organophosphorus triester degradation. The bacterial phosphotriesterases purified and characterized to date hydrolyze mainly aryl dialkyl phosphates, suc...
Aquat. Toxicol. 160 , 163-71, (2015)
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant that is detectable in the environment and biota, prompting concern over its risk to wildlife and human health. Our o...
Environ. Health Perspect. 121 , 580-5, (2013)
A reduction in the use of polybrominated diphenyl ethers (PBDEs) because of human health concerns may result in an increased use of and human exposure to organophosphate flame retardants (OPFRs). Huma...