Bismaleimide

Suppliers

Names

[ CAS No. ]:
13676-54-5

[ Name ]:
Bismaleimide

[Synonym ]:
bismaleimides
mb-3000
matrimid5258
1,1'-(methylenedi-4,1-phenylene)bismaleimide
4,4'-Bismaleimidodiphenylmethane
4,4'-Methylenebis(N-phenylmaleimide)
MFCD00005507
Bis(4-maleimidophenyl)methane
N,N'-(methylenedi-p-phenylene)dimaleimide
1,1'-(Methylenebis(4,1-phenylene))bis(1H-pyrrole-2,5-dione)
MB-3000H
Diphenylmethanebismaleimide
EINECS 237-163-4
4,4'-diphenylmethanebismaleimide
xu292a
BMI

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
584.9±43.0 °C at 760 mmHg

[ Melting Point ]:
156-158 °C(lit.)

[ Molecular Formula ]:
C21H14N2O4

[ Molecular Weight ]:
358.347

[ Flash Point ]:
278.3±20.5 °C

[ Exact Mass ]:
358.095367

[ PSA ]:
74.76000

[ LogP ]:
1.95

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.690

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON5670000
CHEMICAL NAME :
Maleimide, N,N'-(methylenedi-p-phenylene)di-
CAS REGISTRY NUMBER :
13676-54-5
BEILSTEIN REFERENCE NO. :
0333986
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C21-H14-N2-O4
MOLECULAR WEIGHT :
358.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
2500 ug/L
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0491-1069 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1310 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 21 (estimated) No. of Female Employees: 7 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H330-H335

[ Precautionary Statements ]:
P260-P284-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R23;R36/37/38

[ Safety Phrases ]:
S26-S45-S37/39

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
ON5670000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Maleic anhydride
  • 4,4′-methylenedianiline
  • (Z)-3-[[4-[[4-(3-carboxyprop-2-enoylamino)phenyl]methyl]phenyl]carbamoyl]prop-2-enoic acid
  • 1,3-Benzenedisulfonyl dichloride
  • N-(3-HYDROXYPHENYL)MALEIMIDE
  • 4-Maleimidophenol
  • 4,4'-CARBONYLBIS(PHTHALIC ANHYDRIDE)
  • 2,2'-(methylenebis(4,1-phenylene))bis(4-((bis(oxiran-2-ylmethyl)amino)methyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione)

DownStream

Articles

6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression.

Chem. Biol. Interact. 228 , 69-78, (2015)

6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol ...

Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer.

Oncotarget 6 , 35667-83, (2015)

To date, many different chemotherapeutic agents have been widely used as common treatments for oral cancers. However, their therapeutic effects have been disappointing, and these agents may have unwan...

Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines.

J. Oral. Pathol. Med. 44 , 420-8, (2015)

The apoptotic activity of methanol extracts of Impatiens balsamina L. (MEIB) and related mechanisms in human oral squamous cell carcinoma (OSCC) cells have been systematically investigated.The effects...


More Articles

Related Compounds

  • Bismaleimide
  • phenyl-1,4-bismaleimide
  • Toluene-2,4-bismaleimide
  • Imide-extended bismaleimide
  • Imide-extended bismaleimide
  • N,N'-1,3-Phenylenebismaleimide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • N-(2-((3-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)ethyl)thiophene-2-sulfonamide
  • tert-Butyl-DL-alanine
  • ethyl 2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)thiazole-4-carboxylate