RG14620

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Names

[ Name ]:
RG14620

[Synonym ]:
MFCD00236445
3-Pyridineacetonitrile, α-[(3,5-dichlorophenyl)methylene]-, (αZ)-
2-(3',5'-Dichlorophenyl)-1-(3''-pyridinyl)acrylonitrile
(2Z)-3-(3,5-Dichlorophenyl)-2-(3-pyridinyl)acrylonitrile
3-Pyridineacetonitrile, α-[(3,5-dichlorophenyl)methylene]-, (αE)-
(2E)-3-(3,5-Dichlorophenyl)-2-(3-pyridinyl)acrylonitrile
3-Pyridineacetonitrile, α-((3,5-dichlorophenyl)methylene)-
RG-14620

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
418.2±45.0 °C at 760 mmHg

[ Melting Point ]:
155 °C

[ Molecular Formula ]:
C₁₄H₈Cl₂N₂

[ Molecular Weight ]:
275.133

[ Flash Point ]:
206.7±28.7 °C

[ Exact Mass ]:
274.006439

[ PSA ]:
36.68000

[ LogP ]:
4.47

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.657

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Photoinstability of some tyrphostin drugs: chemical consequences of crystallinity.

Pharm. Res. 12(11) , 1708-15, (1995)

The purpose of this work was to study the photostability of the antiproliferative tyrphostin drug compounds RG 13022(I) and RG 14620(II) as a part of preformulation program.The compounds were exposed ...

Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.

J. Cell Physiol. 211(3) , 803-15, (2007)

Inhibiting epidermal growth factor-receptor (ErbB-1) represents a powerful anticancer strategy. Activation of retinoid pathways is also in development for cancer treatment. Retinoic acid receptor-beta...

[Effect of signal transduction inhibitors on human endometrial carcinoma cells with differential PTEN gene expression].

Zhonghua Fu Chan Ke Za Zhi 44(9) , 681-5, (2009)

To investigate the apoptotic and proliferation effects of signal transduction inhibitors on human endometrial carcinoma cells with different PTEN gene expression.PTEN antisense oligonucleotide and pcD...