1,4-Dihydro-4-oxoquinoline-3-carboxylic acid

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Names

[ CAS No. ]:
13721-01-2

[ Name ]:
1,4-Dihydro-4-oxoquinoline-3-carboxylic acid

[Synonym ]:
4-Hydroxyquinoline-3-carboxylic acid
4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1,4-Dihydro-4-oxoquinoline-3-carboxylic acid
1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid
4-Hydroxy-3-quinolinecarboxylic acid
3-Quinolinecarboxylic acid, 4-hydroxy-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
384.7±32.0 °C at 760 mmHg

[ Melting Point ]:
269-270℃

[ Molecular Formula ]:
C10H7NO3

[ Molecular Weight ]:
189.167

[ Flash Point ]:
186.5±25.1 °C

[ Exact Mass ]:
189.042587

[ PSA ]:
70.16000

[ LogP ]:
3.44

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.730

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
22

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl 4-hydroxyquinoline-3-carboxylate
  • Ethyl 4-hydroxy-3-quinolinecarboxylate
  • Propanedioic acid,2-[(phenylamino)methylene]-, 1,3-diethyl ester
  • Methyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
  • Dimethyl (2Z)-2-anilino-2-butenedioate
  • 3-methoxycarbonyl-4-oxo-1H-quinoline-2-carboxylate
  • dimethyl 4-oxo-1H-quinoline-2,3-dicarboxylate

DownStream

  • Ivacaftor (VX-770)
  • N-(5-(TERT-BUTYL)-3,3-DIMETHYL-2-OXO-2,3-DIHYDROBENZOFURAN-6-YL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

  • 8-acetyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • 7-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • 1-Benzyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • 1,8-ethano-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • 1,8-propano-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • 1-ethyl-7-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • [5-(1-methoxyethyl)-1-(pentan-3-yl)-1H-1,2,3-triazol-4-yl]methanol
  • 2-[4-(aminomethyl)-5-cyclopropyl-1H-1,2,3-triazol-1-yl]propan-1-ol
  • 4-(1-Amino-3-methylbutyl)-2,3-dichlorophenol
  • 5-bromo-2-(2H3)methylpyrimidin-4-ol
  • 3-(1-Aminocyclobutyl)-3-hydroxy-8lambda6-thiabicyclo[3.2.1]octane-8,8-dione
  • 4-(1-Aminocyclopentyl)-2,2,6,6-tetramethylpiperidin-4-ol
  • 3-(1-Aminocyclopentyl)-3-hydroxy-1lambda6-thiolane-1,1-dione
  • 1-(1-Aminocyclopentyl)-3-(trifluoromethyl)cyclohexan-1-ol
  • 2-[(3aS,7aS)-octahydro-1H-indol-2-yl]ethan-1-ol
  • rac-(3R,4S)-4-(4,4,4-trifluorobutyl)pyrrolidin-3-ol
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