CO-1686(AVL-301)

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Names

[ CAS No. ]:
1374640-70-6

[ Name ]:
CO-1686(AVL-301)

[Synonym ]:
N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)prop-2-enamide
(N-(3-(2-(4-(4-acetylpiperazin-1-yl)-2-methoxyphenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)phenyl)acrylamide)
UNII: 72AH61702G
CO-1686
CO-1686(AVL-301)
2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-
N-(3-{[2-{[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino}-5-(trifluoromethyl)-4-pyrimidinyl]amino}phenyl)acrylamide
Rociletinib
CO 1686
S7284,CNX-419,AVL-301
Rociletinib(CO-1686)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C27H28F3N7O3

[ Molecular Weight ]:
555.552

[ Exact Mass ]:
555.220581

[ PSA ]:
118.44000

[ LogP ]:
2.38

[ Index of Refraction ]:
1.632

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
23-25-36

[ Safety Phrases ]:
24

[ HS Code ]:
29335990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-Boc-m-phenylenediamine
  • 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
  • tert-Butyl (3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)carbamate
  • N-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

DownStream

Related Compounds

  • CO-1686 hydrobromide
  • tert-Butyl (3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)carbamate
  • [Co(O2CCBr3)2(2,2,5,5-tetramethylpyrrolinyl 1-oxy radical)]2
  • Co-isobutyrate
  • (CO)2Ni(P(C4H9-n)3)2
  • [Co(O2CCCl3)2(2,2,5,5-tetramethylpiperidinyl-1-oxy radical)]2
  • 3-{[(Tert-butoxy)carbonyl]amino}-3-(3-methyl-1,2,4-thiadiazol-5-yl)cyclobutane-1-carboxylic acid
  • 3-{[(Tert-butoxy)carbonyl]amino}-3-(2-chlorothiophen-3-yl)cyclobutane-1-carboxylic acid
  • {4,4-Difluorospiro[2.2]pentan-1-yl}methanesulfonylchloride
  • 4-fluoro-1,3-dimethyl-1H-pyrazole-5-sulfinic acid
  • lithium(1+) ion 4-fluoro-1,3-dimethyl-1H-pyrazole-5-sulfinate
  • 3-(1,1-dioxo-1lambda6-thiolan-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • 3-[(2S)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}piperidin-2-yl]propanoic acid
  • 2-{[(9H-fluoren-9-yl)methoxy]carbonyl}-2-azabicyclo[4.1.0]heptane-7-carboxylic acid
  • Potassium {1-[(tert-butoxy)carbonyl]-4-methylpiperidin-4-yl}trifluoroboranuide
  • 2-[2-(2,5-Dichlorothiophen-3-yl)ethyl]-1,4,5,6-tetrahydropyrimidin-5-ol
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