L-Leucic acid

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Names

[ Name ]:
L-Leucic acid

[Synonym ]:
(S)-2-hydroxy-4-methyl-Pentanoic acid
L-Leucic Acid
(S)-2-Hydroxy-4-methylvaleric Acid
S-2-Hydroxy-4-methylpentanoic acid
(S)-leucic acid
(S)-2-Hydroxy-4-methylpentanoic acid
EINECS 237-329-6
(+)-2-hydroxyisocaproic acid
(S)-(？)-2-Hydroxyisocaproic acid
(2S)-2-hydroxy-4-methyl-pentanoic acid
Pentanoic acid, 2-hydroxy-4-methyl-, (2S)-
L-alpha-Hydroxyisocaproic acid
MFCD00064214
(2S)-2-Hydroxy-4-methylpentanoic acid
(+)-α-Hydroxyisocaproic acid

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
251.3±13.0 °C at 760 mmHg

[ Melting Point ]:
78-80ºC(lit.)

[ Molecular Formula ]:
C₆H₁₂O₃

[ Molecular Weight ]:
132.158

[ Flash Point ]:
120.1±16.3 °C

[ Exact Mass ]:
132.078644

[ PSA ]:
57.53000

[ LogP ]:
0.71

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.458

[ Storage condition ]:
-15°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

L-leucine
ethyl (S)-2-bromo-4-methylpentanoate
Ketoleucine
L-α-Aminooxy-γ-methyl-pentansaeure-(1)
2-Amino-4-methylpentanoic acid
trichodepsipeptide B

DownStream

4-Methylpentanoic acid
DL-Leucic Acid
Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-
tert-Butyl L-2-hydroxy-4-methylpentanoate
(R)-Leucic acid
(S)-(-)-Ethyl Leucate
Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-, 1,1-dimethylethyl ester, (2R)-

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Renal clearance of branched-chain L-amino and 2-oxo acids in maple syrup urine disease.

J. Inherit. Metab. Dis. 22(6) , 706-22, (1999)

In maple syrup urine disease (MSUD), branched-chain L-amino (BCAA) and 2-oxo acids (BCOA) accumulate in body fluids owing to an inherited deficiency of branched-chain 2-oxo acid dehydrogenase complex ...

Rapid diagnosis of phenylketonuria and other aminoacidemias by quantitative analysis of amino acids in neonatal blood spots by gas chromatography-mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 775(1) , 115-20, (2002)

A new method for quantifying specific amino acids in small volumes of plasma and whole blood has been developed. Volatile derivatives of amino acids are analyzed by gas chromatography-mass spectrometr...

Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid.

Clin. Chim. Acta 140(2) , 157-66, (1984)

A method is described in which ammonia chemical ionization gas chromatography-mass spectrometry was utilized in the selected ion monitoring mode to provide an accurate, selective approach to the quant...

L-leucic acid tert-butyl ester
dl-leucic acid isopropyl ester
acetyl-L-leucic acid ethyl ester
(R)-Leucic acid
1-Naphthol-5-sulfonic acid
D-Mevalonolactone
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
N-(2-(furan-2-yl)-2-(1H-pyrazol-1-yl)ethyl)-2-(o-tolyloxy)acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide