1,5,6,7-Tetrahydro-4H-indol-4-one

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Names

[ CAS No. ]:
13754-86-4

[ Name ]:
1,5,6,7-Tetrahydro-4H-indol-4-one

[Synonym ]:
4,5,6,7-Tetrahydro-4-oxoindole
6,7-Dihydro-1H-indol-4(5H)-one
1,5,6,7-Tetrahydro-4H-indol-4-one
4-Oxo-4,5,6,7-tetrahydroindole
MFCD00075438

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
310.6±11.0 °C at 760 mmHg

[ Melting Point ]:
188-190 °C(lit.)

[ Molecular Formula ]:
C8H9NO

[ Molecular Weight ]:
135.163

[ Flash Point ]:
149.6±26.7 °C

[ Exact Mass ]:
135.068420

[ PSA ]:
32.86000

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.592

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6,7-Dihydro-4(5H)-benzofuranone
  • benzyl 4-oxo-4,5,6,7-tetrahydro-1H-indole-1-carboxylate
  • 2-ethoxy-3,5,6,7-tetrahydro-2H-1-benzofuran-4-one
  • dibutoxyphosphinothioyl diethylamino trisulfide
  • 3-[(2,2-diethoxyethyl)amino]cyclohex-2-en-1-one
  • 3-((2-hydroxyethyl)amino)cyclohex-2-enone
  • 1,3-Cyclohexanedione
  • (S)-3-((1S,2R,3R,4R)-1,2,3,4,5-pentahydroxypentyl)-2,3,6,7-tetrahydro-1H-indol-4(5H)-one
  • 2-Aminoethanol

DownStream

  • 1-Methyl-1,5,6,7-tetrahydro-4H-indol-4-one
  • L(-)-Tryptophan
  • 1H-Indole-2-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)
  • 4,5,6,7-Tetrahydro-1H-indole
  • 1-Tosyl-6,7-dihydro-1H-indole-4(5H)-one
  • 4-(2-pyrrolidin-1-yl-ethyl)-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde
  • indol-4-ol
  • 4-Hydroxyindole
  • tert-butyl 4-oxo-4,5,6,7-tetrahydro-1H-indole-1-carboxylate
  • 1,4,5,6,7,8-hexahydropyrrolo[3,2-b]azepine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Direct α-iodination of aryl alkyl ketones by elemental iodine activated by 1-chloromethyl-4-fluoro-1, 4-diazoniabicyclo [2.2. 2] octane bis (tetrafluoroborate). Jereb M, et al.

Synthesis 06 , 0853-0858, (2003)

DNA binders: 1. evaluation of DNA-interactive ability, design, and synthesis of novel intercalating agents Sechi M, et al.

Lett. Drug Des. Discov. 6(1) , 56-62, (2009)

Synthesis of pyrrolo [1, 2-a] indole-1, 8 (5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest. Sechi M, et al.

ARKIVOC 5 , 97-106, (2004)


More Articles

Related Compounds

  • 2-Bromo-1,5,6,7-tetrahydro-4H-indol-4-one
  • 2-cyano-1,5,6,7-tetrahydro-4H-indol-4-one
  • 1-Methyl-1,5,6,7-tetrahydro-4H-indol-4-one
  • 2-methyl-1,5,6,7-tetrahydro-4H-indol-4-one
  • 3-acetyl-1,5,6,7-tetrahydro-4H-indol-4-one
  • 1-benzyl-1,5,6,7-tetrahydro-4h-indol-4-one