GR 64349

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Names

[ CAS No. ]:
137593-52-3

[ Name ]:
GR 64349

[Synonym ]:
1-Lithio-2-methylnaphthalin, lithium
1-lithio-2-methylnaphthalene

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
1342.8ºC at 760mmHg

[ Molecular Formula ]:
C42H68N10O11S

[ Molecular Weight ]:
921.11500

[ Flash Point ]:
765.9ºC

[ Exact Mass ]:
920.47900

[ PSA ]:
372.87000

[ LogP ]:
1.98680

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • boc-freidinger's lactam
  • N-(tert-butoxycarbonyl)-D-methionyl-L-leucine methyl ester
  • Fmoc-Val-OPfp
  • Fmoc-Phe-OPfp
  • Fmoc-Met-OH

DownStream

Articles

Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord.

Br. J. Pharmacol. 115(6) , 1013-9, (1995)

1. The effects of selective tachykinin (neurokinin, NK) NK1 and NK2 receptor antagonists have been examined on spinal neurones in alpha-chloralose anaesthetized, spinalized rats. They were tested for ...

Tachykinin receptor types: Classification and membrane signalling mechanisms.

Neurochem. Int. 18 , 149-165, (1991)

The use of selective agonists in both functional and binding studies has provided unequivocal evidence for the existence of three types of tachykinin receptor (NK(1), NK(2) and NK(3)); there is also p...

Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.

Neuropeptides 19 , 127-135, (1991)

The pharmacological profiles of two novel neurokinin agonists have been investigated. delta Ava[L-Pro9,N-MeLeu10]SP(7-11) (GR73632) and [Lys3,Gly8-R-gamma-lactam-Leu9] NKA(3-10) (GR64349) are potent a...


More Articles

Related Compounds

  • GR 144053 trihydrochloride
  • GR 46611
  • GR 49336
  • GR 135531
  • GR 203040
  • GR 159897
  • 4-[4-(Benzenesulfonyl)piperidin-1-yl]-6-ethyl-5-fluoropyrimidine
  • N-[1-(3-Cyanopyrazin-2-yl)azetidin-3-yl]-N-methyl-1,3-thiazole-4-carboxamide
  • 5-Ethyl-2-{[1-(pyridine-3-carbonyl)piperidin-4-yl]oxy}pyrimidine
  • N-[1-(3-Cyanopyrazin-2-yl)azetidin-3-yl]-3-(difluoromethyl)-N,1-dimethylpyrazole-4-carboxamide
  • N-[1-(3-Cyanopyrazin-2-yl)azetidin-3-yl]-N-methyl-3-(3-methylthiophen-2-yl)propanamide
  • N-[1-(3-Cyanopyrazin-2-yl)azetidin-3-yl]-N-methylmorpholine-4-carboxamide
  • 4-[4-(Benzenesulfonyl)piperidin-1-yl]-6-(trifluoromethyl)pyrimidine
  • 1-(2-Methoxypyridin-4-yl)-4-(1,3-thiazole-4-carbonyl)piperazin-2-one
  • 2-[[1-(6-Ethyl-5-fluoropyrimidin-4-yl)piperidin-3-yl]methoxy]pyridine-4-carbonitrile
  • 4-Bromo-N-[1-(3-cyanopyrazin-2-yl)azetidin-3-yl]-N-methylthiophene-2-carboxamide
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