Valsartan

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Names

[ CAS No. ]:
137862-53-4

[ Name ]:
Valsartan

[Synonym ]:
Valsartan
(S)-N-(1-Carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amine
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-L-valine
N-Pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine
N-Pentanoyl-N-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}valine
N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
(2S)-3-Methyl-2-(pentanoyl{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}amino)butanoic acid
N-[p-(o-1H-Tetrazol-5-ylphenyl)benzyl]-N-valeryl-L-valine
3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid
Nisis
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valin
(2S)-3-Methyl-2-(pentanoyl{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}amino)butanoic acid
Valsratan
N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
Tareg
DIOVAN
L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
Valsartane
Valsartan API
(S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid
L-Valsartan
MFCD00865840

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
684.9±65.0 °C at 760 mmHg

[ Melting Point ]:
116-117°C

[ Molecular Formula ]:
C24H29N5O3

[ Molecular Weight ]:
435.519

[ Flash Point ]:
368.0±34.3 °C

[ Exact Mass ]:
435.227051

[ PSA ]:
112.07000

[ LogP ]:
4.75

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.587

[ Storage condition ]:
-20°C Freezer, Under inert atmosphere

[ Stability ]:
Hygroscopic

MSDS

Safety Information

[ Hazard Statements ]:
H413

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Precursor & DownStream

Precursor

  • N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester
  • (S)-4-isopropyl-3-pentanoyl-2-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-yl]oxazolidin-5-one
  • (2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid
  • Valsartan benzyl ester
  • Valsartan Methyl Ester
  • 5-(2-Bromophenyl)-1-trityl-1H-tetrazole
  • (S)-METHYL 3-METHYL-2-(N-((2'-(1-TRITYL-1H-TETRAZOL-5-YL)-[1,1'-BIPHENYL]-4-YL)METHYL)PENTANAMIDO)BUTANOATE
  • N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine methyl ester
  • Trityl Valsartan

DownStream

  • Hydrochlorothiazide

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A lab-on-a-chip device for analysis of amlodipine in biological fluids using peroxyoxalate chemiluminescence system.

Luminescence 29(8) , 1148-53, (2014)

A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip devic...

Development and Validation of a LC-MS/MS Method for the Simultaneous Estimation of Amlodipine and Valsartan in Human Plasma: Application to a Bioequivalence Study.

Sci. Pharm. 82(3) , 585-600, (2015)

A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric (LC-MS/MS) method has been developed and validated that employs solid-phase extraction for the simultaneous estimation o...

Comparative study between derivative spectrophotometry and multivariate calibration as analytical tools applied for the simultaneous quantitation of Amlodipine, Valsartan and Hydrochlorothiazide.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 113 , 215-23, (2013)

Four simple, accurate and specific methods were developed and validated for the simultaneous estimation of Amlodipine (AML), Valsartan (VAL) and Hydrochlorothiazide (HCT) in commercial tablets. The de...


More Articles


Related Compounds

  • Valsartan
  • Valsartan
  • valsartan
  • D-Valsartan
  • VALSARTAN-D3
  • Valsartan D9
  • 5-(2-Furanyl)-1,2,3,4,5,6-hexahydro-7H-cyclopenta[b]pyridin-7-one
  • 1-Amino-2-(4-chloro-2-fluorophenyl)propan-2-ol
  • 3-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenol
  • 2-((3-formyl-1H-indol-4-yl)oxy)acetonitrile
  • N,N-Diethyl-2-methoxy-6-[2-(4-methoxyphenyl)ethyl]benzamide
  • 2,4-Dichloro-6-isobutylpyrimidine
  • 3-(5-Methoxy-1,2,4-oxadiazol-3-yl)benzoic acid
  • 4-(4-Chloro-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
  • 5-(2-Isopropyl-5-isothiocyanato-4-methoxy-phenoxy)-pyrimidine-2,4-diamine
  • Methyl 2-chloro-3-[4-(2-hydroxyethyl)phenyl]propanoate
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