INH2BP

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Names

[ CAS No. ]:
137881-27-7

[ Name ]:
INH2BP

[Synonym ]:
5-Iabp
INH2BP
2H-1-Benzopyran-2-one,6-amino-5-iodo
PARP Inhibitor II,INH2BP
5-Iodo-6-amino-1,2-benzopyrone
MFCD00912555

Chemical & Physical Properties

[ Density]:
2.029g/cm3

[ Boiling Point ]:
437.6ºC at 760mmHg

[ Molecular Formula ]:
C9H6INO2

[ Molecular Weight ]:
287.05400

[ Flash Point ]:
218.4ºC

[ Exact Mass ]:
286.94400

[ PSA ]:
56.23000

[ LogP ]:
2.56100

[ Vapour Pressure ]:
7.4E-08mmHg at 25°C

[ Index of Refraction ]:
1.737

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

Articles

The Protective Effect of INH2BP, a Novel PARP Inhibitor 5-Iodo-6-Amino-1,2-Benzopyrone, Against Hydrogen Peroxide-Induced Apoptosis Through ERK and p38 MAPK in H9c2 Cells.

Pharmacology 96 , 259-70, (2015)

INH2BP (5-iodo-6-amino-1,2-benzopyrone), a poly-ADP ribose polymerase inhibitor, has been shown to possess anti-cancer, anti-viral, and anti-inflammation properties. The aim of this study was to inves...

4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase.

Arthritis. Res. Ther. 10 , R107, (2008)

4-Hydroxynonenal (HNE) is one of the most abundant and reactive aldehydes of lipid peroxidation products and exerts various effects on intracellular and extracellular signalling cascades. We have prev...

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells.

Breast Cancer Res. Treat. 147(3) , 539-50, (2014)

The unique metabolism of breast cancer cells provides interest in exploiting this phenomenon therapeutically. Metformin, a promising breast cancer therapeutic, targets complex I of the electron transp...


More Articles

Related Compounds

  • Methyl 2-chloro-6-(1-cyanoethyl)-3-methoxybenzoate
  • 3-Bromo-5-phenylpyrazolo[1,5-A]pyrimidine
  • (R)-1-Methyl-3-(trifluoromethyl)piperazine
  • (R)-1-Methyl-2-(trifluoromethyl)piperazine
  • (2R,3R)-2-(3-Fluorophenyl)pyrrolidin-3-ol
  • (2S)-2-amino-3-(5-methylpyrazin-2-yl)propanoic acid
  • (1S)-1-{4H,5H,6H-cyclopenta[b]thiophen-2-yl}ethan-1-amine
  • (1R)-1-{4H,5H,6H-cyclopenta[b]thiophen-2-yl}ethan-1-amine
  • [1-(1,4-dimethyl-1H-pyrazol-5-yl)cyclobutyl]methanamine
  • 2-[1-(1,4-dimethyl-1H-pyrazol-3-yl)cyclopropyl]ethan-1-amine
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