Norepinephrine
Suppliers
Names
[ CAS No. ]:
138-65-8
[ Name ]:
Norepinephrine
[Synonym ]:
1-(3,4-Dihydroxy)phenyl-2-aminoethanol
(-)-NORADRENALINE
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)-
4-[(1R)-2-amino-1-hydroxyéthyl]benzène-1,2-diol
L-NOREPINEPHRINE
(+)-Norepinephrin
4-((R)-2-Amino-1-hydroxy-ethyl)-benzene-1,2-diol
1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-
(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol
EINECS 205-337-9
4-(1-Hydroxy-2-aminoethyl)catechol
R-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol
norepinephrinum [INN_la]
noradrenaline
DL-ARTERENOL
1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)-
[3H]-(+/-)-Norepinephrine
3,4-Dhydroxyphenylethanolamine
L-NORADRENALINE
(R)-(-)-norepinephrine
DL-NOREPINEPHRINE
(+/-)-Norepinephrine
(-)-a-(Aminomethyl)protocatechuyl alcohol
4-[(1R)-2-Amino-1-hydroxyethyl]benzol-1,2-diol
Noradrenalin
[14C]-(+/-)-Norepinephrine
(-)-norepinephrine
(R)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol
(R)-norepinephrine
Racemic norepinephrine
(R)-noradrenaline
4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol
MFCD00066505
(-)-(R)-Norepinephrine
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-
DL-Noradrenaline
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
4-[(1RS)-2-amino-1-hydroxyethyl]-1,2-benzenediol
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
442.6±40.0 °C at 760 mmHg
[ Melting Point ]:
-190ºC (dec.)
[ Molecular Formula ]:
C8H11NO3
[ Molecular Weight ]:
169.178
[ Flash Point ]:
221.5±27.3 °C
[ Exact Mass ]:
169.073898
[ PSA ]:
86.71000
[ LogP ]:
-0.88
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.659
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DN6300000
- CHEMICAL NAME :
- Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (+-)-
- CAS REGISTRY NUMBER :
- 138-65-8
- LAST UPDATED :
- 199106
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C8-H11-N-O3
- MOLECULAR WEIGHT :
- 169.20
- WISWESSER LINE NOTATION :
- Z1YQR CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,501,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,501,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,64,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4700 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949
Safety Information
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R28
[ Safety Phrases ]:
S28;S45;S36/S37/S39
[ WGK Germany ]:
3
[ RTECS ]:
DN6300000
[ HS Code ]:
2922509090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%