Agomelatine

Suppliers

Names

[ CAS No. ]:
138112-76-2

[ Name ]:
Agomelatine

[Synonym ]:
Unii-137R1N49ad
N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide
Acetamide, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-
Aglomelatine
Agomelatine
N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide S-20098
AGOMELATIN
Valdoxan
N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetamide
N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide
Melitor
Thymanax

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
478.8±28.0 °C at 760 mmHg

[ Melting Point ]:
107-109ºC

[ Molecular Formula ]:
C15H17NO2

[ Molecular Weight ]:
243.301

[ Flash Point ]:
243.4±24.0 °C

[ Exact Mass ]:
243.125931

[ PSA ]:
38.33000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC5956323
CHEMICAL NAME :
Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-
CAS REGISTRY NUMBER :
138112-76-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H17-N-O2
MOLECULAR WEIGHT :
243.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5318994

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ Hazard Codes ]:
N

[ Risk Phrases ]:
50

[ Safety Phrases ]:
61

[ RIDADR ]:
UN 3077 9 / PGIII

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanoic anhydride
  • (7-Methoxy-1-naphthyl)acetonitrile
  • 7-methoxy-1-Naphthaleneethanamine
  • N-(2-(7-Methoxy-3,4-dihydronaphthalen-1-yl)ethyl)acetamide
  • 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride
  • Acetyl chloride
  • Dimethyl sulfate
  • 7-Desmethylagomelatine

DownStream

  • 7-Desmethylagomelatine
  • N-[2-(3-bromo-7-methoxynaphthalen-1-yl)ethyl]acetamide

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

[The activity of glutathione antioxidant system at melaksen and valdoxan action under experimental hyperthyroidism in rats].

Biomed. Khim. 59(5) , 541-9, (2013)

Investigation of glutathione antioxidant system activity and diene conjugates content in rats liver and blood serum at the influence of melaksen and valdoxan under experimental hyperthyroidism (EG) ha...

[Tachycardia and precordial pain with agomelatine: a case report].

Therapie. 68(5) , 324-5, (2013)

Agomelatine, melatonin and depressive disorder.

Expert Opin. Investig. Drugs 22(4) , 407-10, (2013)

Alteration of nocturnal melatonin production, along with circadian rhythm disturbance, has been demonstrated in several psychiatric disorders. It has been postulated that such disturbances might be ca...


More Articles

Related Compounds

  • Agomelatine-d4
  • Agomelatine D6
  • 3-Hydroxy agomelatine
  • Agomelatine Dimer Urea
  • Agomelatine Impurity I
  • Agomelatine Impurity D