C-1311

Suppliers

Names

[ Name ]:
C-1311

[Synonym ]:
5-[[(diethylamino)ethyl]amino]-8-hydroxyimidazo[4,5,1-de]-acridine-6-one
C 1311
XLS-002
6H-Imidazo(4,5,1-de)acridin-6-one,5-((2-(diethylamino)ethyl)amino)-8-hydroxy
5-((2-(Diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
605.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₂N₄O₂

[ Molecular Weight ]:
350.41400

[ Flash Point ]:
320.2ºC

[ Exact Mass ]:
350.17400

[ PSA ]:
69.87000

[ LogP ]:
2.97100

[ Vapour Pressure ]:
2.86E-15mmHg at 25°C

[ Index of Refraction ]:
1.68

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,6-DICHLORO-3-NITROBENZOIC ACID
1-Chloro-7-hydroxy-4-nitro-9(10H)-acridinone
2,6-Dichlorobenzoic acid

DownStream

Articles

DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells.

J. Pharmacol. Exp. Ther. 346(3) , 393-405, (2013)

Imidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the uni...

Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.

Drug Metab. Dispos. 41(2) , 414-21, (2013)

The acridinone derivates 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) are promising antitumor agents with high activ...

Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form.

J. Pharm. Biomed. Anal. 39(1-2) , 46-53, (2005)

C1311 (5-[[2-(diethylamino)ethyl]amino]-8-hydroxyimidazo [4,5,1-de]-acridin-6-one-dihydrochloride trihydrate) is the lead compound from the group of imidazoacridinones, a novel group of rationally des...

C-1311 dihydrochloride
C-ethyl (5-sulpho-2-naphthyl)carbamate
C(14a)-Homo-27-nor-14beta-gammaceran-3alpha-ol
C(14a)-Homo-27-nor-5α-gammacera-12,14-diene-3β,21α-diol
C-(1-CYCLOPENTYL-PIPERIDIN-4-YL)-METHYLAMINE
C-(1-BENZYL-1H-PYRAZOL-4-YL)-METHYLAMINE HYDROCHLORIDE
[2-(3,4-Dimethoxyphenyl)ethyl][(6-methylpyridin-2-yl)methyl]amine dihydrochloride
[2-(1H-Indol-3-yl)ethyl][(6-methylpyridin-2-yl)methyl]amine dihydrochloride
3-(4-Amino-pyrazol-1-yl)propan-1-ol hydrochloride
2-Methyl-3-(quinoxalin-2-yl)propanoic acid
4-Amino-3-methyl-1,2-thiazole-5-carboxylic acid hydrochloride
Biotin-PEG3-COOH
Biotin-peg5-alcohol
N-(14-Amino-3,6,9,12-tetraoxatetradecyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
2-(3-Fluoro-4-methoxyphenyl)pyrrolidine hydrochloride
3,5-Dichlorobenzyl piperazine-1-carboxylate hydrochloride

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