Pantoprazole sodium

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Names

[ CAS No. ]:
138786-67-1

[ Name ]:
Pantoprazole sodium

[Synonym ]:
Pantoprazole
MFCD01658543
sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide
Sodium 6-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide
Pantoprazole sodium
1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
protium
Sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl}benzimidazol-1-ide
1H-benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt
Protonix
5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium
1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
Pantoprazole Sodium Salt
Pantoprazole (sodium)

Chemical & Physical Properties

[ Boiling Point ]:
586.9ºC at 760 mmHg

[ Melting Point ]:
199-202ºC

[ Molecular Formula ]:
C16H14F2N3NaO4S

[ Molecular Weight ]:
405.35200

[ Flash Point ]:
308.7ºC

[ Exact Mass ]:
405.05700

[ PSA ]:
94.68000

[ LogP ]:
3.53580

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD8264000
CHEMICAL NAME :
1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)me thyl)sulfinyl)-, sodium salt
CAS REGISTRY NUMBER :
138786-67-1
LAST UPDATED :
199503
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H14-F2-N3-O4-S.Na
MOLECULAR WEIGHT :
405.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
747 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
256 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
395 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990

Safety Information

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22-37/38-41-48

[ Safety Phrases ]:
S22-26-36/37/39-45

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • pantoprazole
  • Pantoprazole Sulfide
  • 2-{[(4-Chloro-3-methoxy-2-pyridinyl)methyl]sulfinyl}-6-(difluorom ethoxy)-1H-benzimidazole
  • 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
  • 2-Chloromethyl-3,4-dimethoxypyridinium chloride
  • 5-(Difluoromethoxy)-2[[(4-chloro-3-methoxy-2-pyridinyl)methyl]-thio]-1H-benzimidazole
  • Sodium Methylate

DownStream

  • pantoprazole

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Pantoprazole sodium
  • Pantoprazole Sodium
  • Pantoprazole sodium
  • Pantoprazole Sodium Hydrate
  • (R)-(+)-Pantoprazole Sodium Salt
  • PANTOPRAZOLE N-OXIDE SODIUM SALT
  • 2-Chloro-4-(difluoromethyl)-5-fluoropyridin-3-ol
  • 2-Cyano-5-(difluoromethyl)-4-nitrobenzoic acid
  • 2-Bromo-6-(difluoromethoxy)nicotinonitrile
  • 2-Bromo-6-(difluoromethyl)-4-fluoronicotinamide
  • 2-Chloro-4-(difluoromethyl)-6-iodo-3-(trifluoromethoxy)pyridine
  • 6-Cyano-2-(difluoromethyl)-5-hydroxynicotinamide
  • 6-Chloro-5-(difluoromethyl)-3-(hydroxymethyl)picolinonitrile
  • 6-Amino-5-chloro-3-(difluoromethyl)pyridin-2-ol
  • 2-Amino-6-(difluoromethyl)-5-(trifluoromethoxy)nicotinic acid
  • (2-Chloro-3-(difluoromethyl)-5-methoxypyridin-4-yl)methanol
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