4-Phenoxyaniline

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Names

[ CAS No. ]:
139-59-3

[ Name ]:
4-Phenoxyaniline

[Synonym ]:
4-phenoxy aniline
Benzenamine,4-phenoxy
EINECS 205-367-2
4-Aminophenyl Phenyl Ether
4-Phenoxyaniline
4-Amino-1-phenoxybenzene
p-Aminophenyl phenyl ether
4-phenoxyanilin
p-Phenoxyaniline
Aniline,p-phenoxy
4-Aminodiphenyl Ether
4-Phenoxybenzenamine
4-phenoxy-phenylamine
Benzenamine, 4-phenoxy-
MFCD00007862

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
320.0±25.0 °C at 760 mmHg

[ Melting Point ]:
82-84 °C(lit.)

[ Molecular Formula ]:
C12H11NO

[ Molecular Weight ]:
185.222

[ Flash Point ]:
155.8±16.4 °C

[ Exact Mass ]:
185.084061

[ PSA ]:
35.25000

[ LogP ]:
2.36

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.619

[ Water Solubility ]:
< 1 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BY7930000
CHEMICAL NAME :
Aniline, p-phenoxy-
CAS REGISTRY NUMBER :
139-59-3
BEILSTEIN REFERENCE NO. :
0777708
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C12-H11-N-O
MOLECULAR WEIGHT :
185.24
WISWESSER LINE NOTATION :
ZR DOR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,683,1988

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H317-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R43;R50/53;R68

[ Safety Phrases ]:
S26-S36/37/39-S61-S45-S24

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BY7930000

[ Packaging Group ]:
I; II; III

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bromobenzene
  • 4-Aminophenol
  • Iodobenzene
  • 4-NITROPHENYL PHENYL ETHER
  • 4-Iodoaniline
  • Phenol
  • 4-Bromoaniline
  • Diphenyl oxide
  • 1-Fluoro-4-nitrobenzene

DownStream

  • 1-(4-Phenoxyphenyl)guanidine
  • 4-phenoxyphenyl isothiocyanate
  • N,N'-bis-(4-phenoxy-phenyl)-thiourea
  • 4-Phenoxyphenyl isocyanate
  • 2-Chloro-N-(4-phenoxyphenyl)acetamide
  • 4-PHENOXYTHIOPHENOL
  • 4-Biphenylol
  • [1,1'-Biphenyl]-2-ol,5-amino-
  • 4-Aminophenol
  • 4-Aminobiphenyl

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.

Eur. J. Med. Chem. 42 , 1396-402, (2007)

Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry...

Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.

Bioorg. Med. Chem. 19 , 261-74, (2011)

Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding...

Mutagenicity of nitroscanate, an antischistosomal drug.

Mutat. Res. 334(3) , 273-81, (1995)

Nitroscanate (NSC) was found to be a direct acting mutagen in the Ames Salmonella tester strains TA100 and TA98 and this activity increased further in the presence of rat liver S9 mix. It was inactive...


More Articles

Related Compounds

  • 2-iodo-4-phenoxyaniline
  • 2-Amino-4-phenoxyaniline
  • N-hexyl-4-phenoxyaniline
  • 2-Amino-4-phenoxyaniline
  • 2-nitro-4-phenoxyaniline
  • 3-bromo-4-phenoxyaniline
  • 1-(1,4-Oxazepan-6-yl)propan-1-one
  • (2-Fluoro-4-(1-methoxy-1-oxopropan-2-yl)phenyl)boronic acid
  • 2-(1-{4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}-N-methylformamido)-2-methylpropanoic acid
  • 3-({4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)-2,2-dimethylpropanoic acid
  • 2-({1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutyl}formamido)-5-methylhex-4-enoic acid
  • 5-(3-Fluoro-4-methoxyphenyl)-1-(propan-2-yl)-1,2,3,6-tetrahydropyridine
  • 3-Chloro-6-(3-phenylphenyl)pyridazine
  • 2-[5-(1H-indol-7-yl)-2-methylphenyl]ethan-1-amine
  • 2-{[1,1'-Biphenyl]-4-carbonyl}-4-methoxy-2-azabicyclo[2.1.1]hexane
  • 3,6-Dicyclopropyl-[1,2]oxazolo[5,4-b]pyridin-4-amine
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