Duramycin

Suppliers

Names

[ Name ]:
Duramycin

[Synonym ]:
UNII-BPR0F3X56H
Lancovutide [INN]
Ancovenin,2-L-lysine-6-(3-aminoalanine)-10-L-phenylalanine-12-L-phenylalanine-13-L-valine-15-(erythro-3-hydroxy-L-aspartic acid)-,cyclic 6-19)-imine
Leucopeptin
LANCOVUTIDE

Chemical & Physical Properties

[ Density]:
1.0238 (rough estimate)

[ Melting Point ]:
271-273ºC

[ Molecular Formula ]:
C₈₉H₁₂₅N₂₃O₂₅S₃

[ Molecular Weight ]:
1999.25000

[ Exact Mass ]:
1997.82000

[ PSA ]:
835.99000

[ Index of Refraction ]:
1.6680 (estimate)

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
0.1 M HCl: soluble10mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV7100000

CHEMICAL NAME :: Ancovenin, 2-L-lysine-6-(3-aminoalanine)-10-L-phenylalanine-12-L -phenylalanine-13-L-v aline- 15-(erythro-3-hydroxy-L-aspartic acid)-, cyclic 6-19)-imine

CAS REGISTRY NUMBER :: 1391-36-2

LAST UPDATED :: 199801

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C89-H125-N23-O25-S3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 17,262,1964

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
BV7100000

Articles

Stimulation of sodium transport by duramycin in cultured human colonic epithelia.

J. Pharmacol. Exp. Ther. 259 , 1050, (1991)

Effects of two peptide antibiotics, duramycin and Ro 09-0198, on ion transport in cultured human colonic epithelia were investigated. Both peptides acted on the apical face of epithelial monolayers, c...

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.

EMBO J. 31 , 4106-23, (2012)

Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism. We recently showed that presenilin-1 and -2, the catalyti...

Phosphatidylethanolamine is externalized at the surface of microparticles.

Biochim. Biophys. Acta 1821(12) , 1501-7, (2012)

Microparticles (MPs) are membrane-bound vesicles shed normally or as a result of various (pathological) stimuli. MPs contain a wealth of bio-active macromolecules. Aminophospholipid phosphatidylserine...