Zanamivir

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Names

[ CAS No. ]:
139110-80-8

[ Name ]:
Zanamivir

[Synonym ]:
5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic Acid
5-(acetylamino)-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid 4-Guanidino-Neu5Ac2en
(6R)-5-Acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-L-threo-hex-2-enonic acid
5-(acetylamino)-4-{[amino(imino)methyl]amino}-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
GANA
D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-
GG 167
Zanamir
Zanamivir
Relenza
Zanamavir
Zanamivir Hydrate
5-Acetamido-4-guanidino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic Acid
5-Acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
Unii-L6o3xi777i

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Melting Point ]:
256ºC (dec.)

[ Molecular Formula ]:
C12H20N4O7

[ Molecular Weight ]:
332.310

[ Exact Mass ]:
332.133209

[ PSA ]:
198.22000

[ LogP ]:
-4.13

[ Index of Refraction ]:
1.679

[ Storage condition ]:
2~8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
RA9451000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1H-Pyrazole-1-carboximidamide hydrochloride
  • Zanamivir
  • Methyl 5-acetamido-7,8,9-O-triacetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonate
  • Aminoiminomethanesulfonic acid
  • 4-a-AMino-N-acetyl-2-deoxy-2,3-didehydro-D-neuraMinate
  • methyl (3aR,4R,7aR)-2-methyl-4-(1S,2R,3-triacetoxypropyl)-3a,7a-dihydro-4H-pyrano[3,4-d]oxazole-6-carboxylate
  • N-Acetyl-S-methylisothiourea

DownStream

Articles

Cochrane researchers continue to face challenges over access to data on flu drugs.

BMJ 346 , f3190, (2013)

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.

J. Med. Chem. 56(3) , 671-84, (2013)

In order to exploit the 430-cavity in the active sites of neuraminidases, 22 zanamivir analogs with C-1 and C-4 modification were synthesized, and their inhibitory activities against both group-1 (H5N...

Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity.

Science 340(6128) , 71-5, (2013)

Influenza antiviral agents play important roles in modulating disease severity and in controlling pandemics while vaccines are prepared, but the development of resistance to agents like the commonly u...


More Articles

Related Compounds

  • Zanamivir
  • Talo-zanamivir
  • Zanamivir Amine
  • zanamivir hydrate
  • Zanamivir hydrate
  • ZANAMIVIR HYDRATE
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-Cyclopropylimidazo[1,5-a]pyridin-1-amine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 3-(2-methoxybenzoyl)-2H-chromen-2-one
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • (5-Methyl-[1,2,4]triazol-1-yl)-acetic acid