Mertansine

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Names

[ CAS No. ]:
139504-50-0

[ Name ]:
Mertansine

[Synonym ]:
UNII-DDZ29HGH0E
DM1 Compound
DM1 [Maytansinoid]
(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2 S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate (non-preferred name)
Maytansine,N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)
DM 1
Mertansine
maytansinoid DM1
N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine
maytansinoid DM 1
N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine

Chemical & Physical Properties

[ Density]:
1.33±0.1 g/cm3

[ Boiling Point ]:
937.1±65.0 °C at 760 mmHg

[ Melting Point ]:
190-192 ºC

[ Molecular Formula ]:
C35H48ClN3O10S

[ Molecular Weight ]:
738.288

[ Flash Point ]:
520.5±34.3 °C

[ Exact Mass ]:
737.274902

[ PSA ]:
198.76000

[ LogP ]:
4.76

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Insuluble (2.4E-4 g/L) (25 ºC)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine
  • (S)-2-(N-Methyl-3-(Methyldisulfanyl)propanamido)propanoic acid
  • Maytansinol

DownStream

Related Compounds

  • Mertansine
  • Cantuzumab mertansine
  • Lorvotuzumab Mertansine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 6-Cyclopropyl-2-[4-[6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]-1,3-diazinan-4-one
  • 2-(4-Bromo-2-methylphenyl)-2,2-difluoroacetic acid
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1-{4-[4-(4-Methoxyphenoxy)piperidine-1-carbonyl]-4-phenylpiperidin-1-yl}prop-2-en-1-one
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde