tris(2-chloroethyl) phosphite

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Names

[ CAS No. ]:
140-08-9

[ Name ]:
tris(2-chloroethyl) phosphite

[Synonym ]:
MFCD00000968
EINECS 205-397-6
TRIS(2-CHLOROETHYL) PHOSPHITE
Phosphorous Acid Tris(2-chloroethyl) Ester

Chemical & Physical Properties

[ Density]:
1.328 g/mL at 25 °C(lit.)

[ Boiling Point ]:
112-115 °C2 mm Hg(lit.)

[ Molecular Formula ]:
C₆H₁₂Cl₃O₃P

[ Molecular Weight ]:
269.49000

[ Flash Point ]:
375 °F

[ Exact Mass ]:
267.95900

[ PSA ]:
41.28000

[ LogP ]:
2.97950

[ Vapour Pressure ]:
0.00359mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.487(lit.)

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK2810000

CAS REGISTRY NUMBER :: 140-08-9

BEILSTEIN REFERENCE NO. :: 1704979

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H12-Cl3-O3-P

MOLECULAR WEIGHT :: 269.50

WISWESSER LINE NOTATION :: G2OPO2GO2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 810 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 21 gm/kg/2D-I

TOXIC EFFECTS :: Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure) Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 333 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311-H315-H319-H330-H335-H340-H350

[ Precautionary Statements ]:
P201-P260-P280-P284-P301 + P310-P305 + P351 + P338

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R45

[ Safety Phrases ]:
S53-S26-S36/37/39-S45-S36/37

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
KK2810000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2920901900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Chloroethanol
ETHYLENE OXIDE
chloro-bis(2-chloroethoxy)phosphane
2-Dimethylamino-1,3-dioxolane
Phosphorus trichloride
Pyridine
Diethyl ether
β-chloroethyldichlorophosphite
Ethanol

DownStream

bis(2-chloroethyl)phosphite
Phosphonic acid,(trichloromethyl)-, bis(2-chloroethyl) ester (8CI,9CI)
BIS(2-CHLOROETHYL) METHYLPHOSPHONATE
bis(2-chloroethyl) hydrogen phosphate
bis(2-chloroethyl) chlorophosphate
dichloroethane
Bis(2-chloroethyl) 2-chloroethylphosphonate
TCEP
2-(2-chloroethoxy)-1,3,2-dioxaphospholane
Phosphonic acid,bis(2-chloroethyl) ester

Customs

[ HS Code ]: 2920901900

[ Summary ]:
2920901900 VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%