Benzathine

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Names

[ CAS No. ]:
140-28-3

[ Name ]:
Benzathine

[Synonym ]:
N,N′-dibenzyl-1,2-ethylenediamine
N,N'-Dibenzylethan-1,2-diamin
N,N′-Dibenzylethylenediamine
1,2-Ethanediamine, N,N-bis(phenylmethyl)-
N,N'-dibenzylethane-1,2-diamine
EINECS 205-408-4
N,N‘-Dibenzylethylenediamine
N,N'-Dibenzyl-1,2-ethanediamine
MFCD00004771
1,2-Ethanediamine, N1,N2-bis(phenylmethyl)-
N,N'-DIBENZYLETHYLENEDIAMINE
Benzathine
N,N-Dibenzylethylenediamine
N1,N2-Dibenzylethane-1,2-diamine
N,N'-Bis(phenylmethyl)-1,2-ethanediamine

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
373.8±22.0 °C at 760 mmHg

[ Melting Point ]:
23-25°C

[ Molecular Formula ]:
C₁₆H₂₀N₂

[ Molecular Weight ]:
240.343

[ Flash Point ]:
220.5±14.1 °C

[ Exact Mass ]:
240.162643

[ PSA ]:
24.06000

[ LogP ]:
2.86

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.571

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KV3325000

CHEMICAL NAME :: Ethylenediamine, N,N'-dibenzyl-

CAS REGISTRY NUMBER :: 140-28-3

BEILSTEIN REFERENCE NO. :: 0786668

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H20-N2

MOLECULAR WEIGHT :: 240.38

WISWESSER LINE NOTATION :: R1M2M1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 388 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
2927

[ WGK Germany ]:
3

[ RTECS ]:
KV3325000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2921590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N1,N2-Dibenzylideneethane-1,2-diamine
Benzaldehyde
1,2-Ethanediamine
N-[2-[benzoyl(benzyl)amino]ethyl]-N-benzylbenzamide
Benzamide,N,N'-1,2-ethanediylbis-
IMIDAZOLIDINE, 1,3-DIBENZYL-2-PHENYL-
Hydrazinecarboxylicacid, 2-(phenylmethylene)-, ethyl ester
Benzyl bromide

DownStream

IMIDAZOLIDINE, 1,3-DIBENZYL-2-PHENYL-
N-Methylbenzylamine
methylamine
N-benzyl-N-[2-[benzyl(formyl)amino]ethyl]formamide
N-[2-[acetyl(benzyl)amino]ethyl]-N-benzylacetamide
ethyl 1,4-dibenzyl-3-oxopiperazine-2-carboxylate
1,4-dibenzyl-1,4-diazepane-5,7-dione
3-OXO-4-(PHENYLMETHYL)-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER
1,4-dibenzylpiperazine-2-carboxamide
1h-1,4-diazepine-5-carboxylic acid, hexahydro-1,4-bis(phenylmethyl)-, methyl ester

Customs

[ HS Code ]: 2921590090

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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