KT-109

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Names

[ CAS No. ]:
1402612-55-8

[ Name ]:
KT-109

[Synonym ]:
(2-Benzyl-1-piperidinyl)[4-(4-biphenylyl)-1H-1,2,3-triazol-1-yl]methanone
Methanone, (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[2-(phenylmethyl)-1-piperidinyl]-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
637.3±53.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H26N4O

[ Molecular Weight ]:
422.522

[ Flash Point ]:
339.3±30.9 °C

[ Exact Mass ]:
422.210663

[ LogP ]:
5.23

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.653

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H413

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Articles

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

Nat. Chem. Biol. 8(12) , 999-1007, (2012)

The endocannabinoid 2-arachidonoylglycerol (2-AG) is biosynthesized by diacylglycerol lipases DAGLα and DAGLβ. Chemical probes to perturb DAGLs are needed to characterize endocannabinoid function in b...

Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.

J. Med. Chem. 56(21) , 8257-69, (2013)

We have previously shown that 1,2,3-triazole ureas (1,2,3-TUs) act as versatile class of irreversible serine hydrolase inhibitors that can be tuned to create selective probes for diverse members of th...

Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.

J. Biol. Chem. 289(3) , 1491-504, (2014)

Perturbation of calcium signaling that occurs during cell injury and disease, promotes cell death. In mouse lung fibroblasts A23187 triggered mitochondrial permeability transition pore (MPTP) formatio...


More Articles


Related Compounds

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  • [(4R,4aR,7R,7aR,12bS)-7-acetylsulfanyl-3-(cyclopropylmethyl)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-9-yl] acetate
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