Chetomin

Suppliers

Names

[ Name ]:
Chetomin

[Synonym ]:
Chetomin,Chaetomiumspecies
CHETOMIN
(1S,3S,11R,14S)-14-(Hydroxymethyl)-3-(3-{[(1S,4S)-4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl}-2,3-dihydro-1H-indol-1-yl)-18-methyl-15,16-dithia-10,12,18 ;-triazapentacyclo[12.2.2.0.0.0]octadeca-4,6,8-triene-13,17-dione
Chetomin,Chaetomin
3,11a-(Iminomethano)-11aH-[1,2,4]dithiazino[4',3':1,5]pyrrolo[2,3-b]indole-4,12(3H)-dione, 10b-[2,3-dihydro-3-[[(1S,4S)-4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-5a,6,10b,11-tetrahydro-3-(hydroxymethyl)-13-methyl-, (3S,5aR,10bS,11aS)-
CS-1
CHAETOMIN
CTM
CHETOMIN(RG)

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Melting Point ]:
710.9ºC

[ Molecular Formula ]:
C₃₁H₃₂N₆O₆S₄

[ Molecular Weight ]:
712.882

[ Exact Mass ]:
712.126587

[ PSA ]:
238.17000

[ LogP ]:
3.85

[ Index of Refraction ]:
1.869

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FM3038000

CHEMICAL NAME :: Chetomin

CAS REGISTRY NUMBER :: 1403-36-7

BEILSTEIN REFERENCE NO. :: 0077366

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C31-H30-N6-O6-S4

MOLECULAR WEIGHT :: 710.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),174,1980

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

J. Antibiot. 65(5) , 263-5, (2012)

Role of hypoxia and autophagy in MDA-MB-231 invasiveness.

J. Cell Physiol. 223(2) , 359-68, (2010)

Survival strategies adopted by tumor cells in response to a hypoxic stress include activation of hypoxia-inducible factor 1 (HIF-1) and autophagy. However, the importance and the function of each mole...

Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix.

J. Am. Chem. Soc. 132(3) , 941-3, (2010)

Designed ligands that inhibit hypoxia-inducible gene expression could offer new tools for genomic research and, potentially, drug discovery efforts for the treatment of neovascularization in cancers. ...

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