PFI-1

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Names

[ Name ]:
PFI-1

[Synonym ]:
2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-6-quinazolinyl)benzenesulfonamide
Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-
QCR-192
PFI-1
CS-1362
PF-6405761

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₁₇N₃O₄S

[ Molecular Weight ]:
347.389

[ Exact Mass ]:
347.093964

[ PSA ]:
96.12000

[ LogP ]:
0.53

[ Appearance of Characters ]:
white to beige

[ Index of Refraction ]:
1.628

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ≥10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition.

Oncotarget 6 , 34669-79, (2015)

Inhibition of BET bromodomains (BRDs) has emerged as a promising cancer therapeutic strategy. Accordingly, inhibitors of BRDs such as JQ1 have been actively developed and some have reached clinical te...

The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors.

Cell Death Dis. 5 , e1450, (2014)

Endogenous c-MYC (MYC) has been reported to be a potential pharmacological target to trigger ubiquitous tumor regression of pancreatic neuroendocrine tumors (PanNETs) and lung tumors. Recently inhibit...

PFI-3
PFI 4
Propane,1,1-bis(ethylsulfonyl)-2-methyl-
Pyridinium, 1- (2-hydroxy[1,1:3,1-terphenyl]-5-yl)-2,4, 6-triphenyl-, perchlorate (salt)
Cyclohexanecarboxylicacid, 1-methyl-3-oxo-, ethyl ester
2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
[(E)-2-[(3S,4R,5S,7S)-7-hydroxy-5-methyl-5-(4-methylpent-3-enyl)-3-(2-oxopropyl)-3,4,6,7-tetrahydro-1H-2-benzofuran-4-yl]ethenyl] 3-methylbut-2-enoate
Methyl 5-amino-2-(4-amino-2-methoxycarbonyl-6-methylphenyl)-3-methylbenzoate
4-(2-Chloroethoxy)-1-butanol
10,15-Dihydro-5H-diindeno[1,2-a:1',2'-c]fluorene-2,3,7,8,12,13-hexaol
Acetic acid, ((2-chloro-4-nitrophenyl)thio)-, 1-methylethyl ester
2-(4-Chlorophenyl)-6-hydroxybenzoxazole
3-Methyl-5-[methyl(phenylmethyl)amino]-2-pentanone
6-(naphthalen-1-yl)-2-(pyridin-2-ylmethyl)pyridazin-3(2H)-one
1-(1,2-Benzisoxazol-3-yl)-2-methyl-1-propanone
N-ethyl-1,5-dimethyl-1H-pyrazole-3-carboxamide

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