Nogalamycin
Suppliers
Names
[ CAS No. ]:
1404-15-5
[ Name ]:
Nogalamycin
[Synonym ]:
antibiotic205t3
nogalomycin
NOGALAMYCIN
NOGALAMYCIN,STREPTOMYCES NOGALATER
Chemical & Physical Properties
[ Density]:
1.49g/cm3
[ Boiling Point ]:
899.9ºC at 760mmHg
[ Molecular Formula ]:
C39H49NO16
[ Molecular Weight ]:
787.80
[ Flash Point ]:
498.1ºC
[ Exact Mass ]:
787.30500
[ PSA ]:
229.44000
[ LogP ]:
1.13800
[ Vapour Pressure ]:
7.49E-35mmHg at 25°C
[ Index of Refraction ]:
1.648
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RA4550000
- CHEMICAL NAME :
- Nogalamycin
- CAS REGISTRY NUMBER :
- 1404-15-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C39-H49-N-O16
- MOLECULAR WEIGHT :
- 787.89
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4600 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13750 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8500 ug/kg
- TOXIC EFFECTS :
- Skin and Appendages - other glands Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 250 ug/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - respiratory depression
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 12 umol/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 36,1,1981 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H312-H332-H350-H360
[ Precautionary Statements ]:
P201-P280-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
45-46-61-20/21/22
[ Safety Phrases ]:
53-22-36/37/39-45
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
RA4550000
Articles
Anal. Biochem. 492 , 34-42, (2015)
Quantitative studies of the binding of various DNA-binding antibiotics with dsDNA are useful for drug design, not only for effective antibiotics, but also for antitumor drugs. We studied the binding k...
J. Mol. Graph. Model. 26(1) , 14-9, (2007)
A variety of molecules bind to DNA in its major and minor grooves, and some, like the anthraquinoids, are known to form intercalates in which these molecules are inserted directly into the double heli...
Antimicrob. Agents Chemother. 47(4) , 1291-6, (2003)
The biosynthesis pathways of two anthracyclines, nogalamycin and aclacinomycin, were directed toward angucyclines by using an angucycline-specific cyclase, pgaF, isolated from a silent antibiotic bios...