3,5-Difluorobenzenesulfonamide

Names

[ CAS No. ]:
140480-89-3

[ Name ]:
3,5-Difluorobenzenesulfonamide

[Synonym ]:
ZSWR CF EF
MFCD02091379
3,5-Difluorobenzenesulfonamide
Benzenesulfonamide, 3,5-difluoro-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
315.9±52.0 °C at 760 mmHg

[ Melting Point ]:
157-161 °C(lit.)

[ Molecular Formula ]:
C₆H₅F₂NO₂S

[ Molecular Weight ]:
193.171

[ Flash Point ]:
144.8±30.7 °C

[ Exact Mass ]:
193.000900

[ PSA ]:
68.54000

[ LogP ]:
1.21

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.534

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ Packaging Group ]:
I

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3,5-Difluorobenzenesulfonyl chloride
3,5-Difluoroaniline

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.

Bioorg. Med. Chem. 21(7) , 2093-106, (2013)

A series of 4-substituted-2,3,5,6-tetrafluorobenezenesulfonamides were synthesized and their binding potencies as inhibitors of recombinant human carbonic anhydrase isozymes I, II, VII, XII, and XIII ...

Fluorine NMR studies of the human carbonic anhydrase-3, 5-difluorobenzenesulfonamide complex Veenstra DL and Gerig JT

Magn. Reson. Chem. 36(S1) , S169-S178, (1998)

4-Bromo-3,5-difluorobenzenesulfonamide
(R)-N-(1-Benzyl-6-bromo-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-3,5-difluorobenzenesulfonamide
3-[5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl]propan-1-ol
3-[(5-methoxy-1H-indol-3-yl)methylidene]-1H-indol-2-one
3,5-dinitro-N-phenacylbenzamide
3,5-diethyl-1-methyl-thiopyran 1-oxide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
5-Amino-4-methyl-3-pyridinemethanol
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide