Glycyrrhizic acid

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Names

[ CAS No. ]:
1405-86-3

[ Name ]:
Glycyrrhizic acid

[Synonym ]:
Glycyrrhizin
Olean-12-en-30-oic acid, 3-[(2-O-β-D-glucopyranuronosyl-α-D-glucopyranuronosyl)oxy]-11-oxo-, (3β)-
Potenlini
Glycyrrhizate
glycyron
DerMacrin
MFCD00167400
20b-Carboxy-11-oxo-30-norolean-12-en-3b-yl-2-O-b-D-glucopyranuronosyl-a-D-glucopyranosiduronic Acid
(3β)-30-Hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid
Glycyrrhizic acid
Glycyrrhizine
liquorice
(3b,20b)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-Glucopyranuronosyl-a-D-glucopyranosiduronic Acid
30-Noroleanane, α-D-glucopyranosiduronic acid deriv
glycyrrhizinic acid
glycyrrhetinic acid glycoside
Glycyrrhitin
Glycyrrhizic
EINECS 258-887-7

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
971.4±65.0 °C at 760 mmHg

[ Melting Point ]:
220ºC decomposes

[ Molecular Formula ]:
C42H62O16

[ Molecular Weight ]:
822.932

[ Flash Point ]:
288.1±27.8 °C

[ Exact Mass ]:
822.403809

[ PSA ]:
267.04000

[ LogP ]:
4.64

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.621

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MD2025000
CHEMICAL NAME :
Glycyrrhizinic acid
CAS REGISTRY NUMBER :
1405-86-3
BEILSTEIN REFERENCE NO. :
0077922
LAST UPDATED :
199706
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C42-H62-O16
MOLECULAR WEIGHT :
823.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
280 mg/kg/4W
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - changes in phosphorus
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
662 mg/kg/1Y-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Nutritional and Gross Metabolic - changes in potassium
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4320 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
589 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :
Micronucleus test
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 367,99,1996

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
MD2025000

[ HS Code ]:
1211903600

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Glycyrrhizin trimethyl ester
  • Penta-acetylglycyrrhizin trimethyl ester

DownStream

  • α-D-Glucopyranuronic acid
  • Glycyrrhetinic acid
  • 2-Acetamidofluorene

Customs

[ HS Code ]: 1211903600

Related Compounds

  • glycyrrhizic acid
  • GLYCYRRHIZIC ACID,NH4
  • Glycyrrhizic acid 2NH4
  • Glycyrrhizic acid zinc salt
  • Glycyrrhizic acid methyl ester
  • Glycyrrhizic acid ammonium salt
  • Trihydrogen tris((4-((2-chlorophenyl)(4-(ethyl(3-sulphonatobenzyl)amino)phenyl)methylene)cyclohexa-2,5-dien-1-ylidene)(ethyl)(3-sulphonatobenzyl)ammonium), aluminium salt
  • Naja naja philippinensis neurotoxin
  • Chromate(2-), (4-((5-chloro-2-hydroxyphenyl)azo)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-))(4-(4,5-dihydro-4-((2-hydroxy-4-nitrophenyl)azo)-3-methyl-5-oxo-1H-pyrazol-1-yl)benzenesulfonato(3-))-, disodium
  • Cobaltate(3-), (2-(4-((8-(benzoylamino)-2-hydroxy-1-naphthalenyl)azo)-3-hydroxybenzoyl)benzoato(3-))(2-(4-((1-(4-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl)azo)-3-hydroxybenzoyl)benzoato(3-))-, trisodium
  • (2-Methylpentane-2,4-diolato(2-)-O,O')bis(pentane-2,4-dionato-O,O')titanium
  • Einecs 284-814-3
  • 4-((4-((4,6-Dichloro-1,3,5-triazin-2-yl)amino)-2-sulphophenyl)azo)-4,5-dihydro-5-oxo-1-(4-sulphophenyl)-1H-pyrazole-3-carboxylic acid, potassium sodium salt
  • Chromate(2-), (2-((4,5-dihydro-3-methyl-5-oxo-1-(4-((1-oxo-2-propenyl)amino)phenyl)-1H-pyrazol-4-yl)azo)-5-nitrobenzoato(2-))(2-((4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo)-4-sulfobenzoato(3-))-, disodium
  • Einecs 286-203-7
  • Chlorpheniramine stearate
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