Diethyl chloromalonate

Names

[ Name ]:
Diethyl chloromalonate

[Synonym ]:
Diethyl 2-chloromalonate
Propanedioic acid, 2-chloro-, diethyl ester
2-CHLORO-MALONIC ACID DIETHYL ESTER
MFCD00009140
Diethyl chloromalonate
EINECS 237-913-0
Diethyl chloro malonate

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
222.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₁₁ClO₄

[ Molecular Weight ]:
194.613

[ Flash Point ]:
103.3±0.0 °C

[ Exact Mass ]:
194.034592

[ PSA ]:
52.60000

[ LogP ]:
1.30

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.439

[ Storage condition ]:
-20?C Freezer, Under Inert Atmosphere

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335-H400

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R34;R36/37

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29171990

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

K2CO3-promoted domino reactions: construction of functionalized 2,3-dihydrobenzofurans and clofibrate analogues.

J. Org. Chem. 76(17) , 7222-8, (2011)

The K(2)CO(3)-catalyzed domino reactions (Michael alkylation, Mannich alkylation, and aldol alkylation) of salicylic aldehyde derivatives (2-hydroxyaryl-α,β-unsaturated ketones, 2-hydroxyarylnitroalke...

Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase.

J. Med. Chem. 26(4) , 559-63, (1983)

Reaction of diethyl chloromalonate with beta-mercapto amines, 9, gave 1,4-thiazin-3-ones, 10, which were alkylated exclusively at the lactam oxygen with triethyloxonium tetrafluoroborate and subsequen...

Preparation of cycloaddition chemistry of thio-and selenocarbonyls derived from reaction of elemental sulfur and selenium with stabilized a-halo anions. Abelman MM.

Tetrahedron Lett. 32(50) , 7389-92, (1990)

diethyl 2-hydroxy-3-(1,2,4-triazol-1-yl)propylphosphonate
diethyl (4-methoxyphenylthio)methylphosphonate
diethyl N-methylaminomethylphosphonate
diethyl 1-cyano-1-(4-isobutylphenyl)ethylphosphate
diethyl 2-(1-ethylsulfanyl-2-methylpropyl)propanedioate
diethyl 2-benzyl-2-pentylpropanedioate
N-(4-chloro-3-fluorophenyl)-2-(10-oxo-3,4,5,10-tetrahydrobenzo[b][1,6]naphthyridin-2(1H)-yl)acetamide
Benzoyl chloride, 3-[[(1-methylethyl)amino]sulfonyl]-
methyl 4-(2-(10-oxo-3,4-dihydrobenzo[b][1,6]naphthyridin-2(1H,5H,10H)-yl)acetamido)benzoate
methyl 4-(2-(8-methyl-10-oxo-3,4-dihydrobenzo[b][1,6]naphthyridin-2(1H,5H,10H)-yl)acetamido)benzoate
2-(6-fluoro-10-oxo-3,4-dihydrobenzo[b][1,6]naphthyridin-2(1H,5H,10H)-yl)-N-(4-(methylthio)benzyl)acetamide
N-(2-chlorobenzyl)-2-(6-methoxy-10-oxo-3,4-dihydrobenzo[b][1,6]naphthyridin-2(1H,5H,10H)-yl)acetamide
2-(6-methyl-10-oxo-3,4-dihydrobenzo[b][1,6]naphthyridin-2(1H,5H,10H)-yl)-N-(4-methylbenzyl)acetamide
Ethyl [(6-{[(4-cyanophenyl)sulfonyl]amino}-2-phenylquinolin-4-yl)oxy]acetate
N-(5-chloro-2,4-dimethoxyphenyl)-2-[3-isopropyl-6-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetamide
1-(4-(5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyridin-2-yl)piperazin-1-yl)-2-((1-methyl-1H-tetrazol-5-yl)thio)ethanone

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