Angiotensin

Names

[ CAS No. ]:
1407-47-2

[ Name ]:
Angiotensin

[Synonym ]:
ANGIOTENSINII,HYPERTENSIN
angiotensin I
Hypertensin

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Molecular Formula ]:
C62H89N17O14

[ Molecular Weight ]:
1296.48000

[ Exact Mass ]:
1295.68000

[ PSA ]:
493.22000

[ LogP ]:
3.83280

[ Index of Refraction ]:
1.679

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BW2275000
CHEMICAL NAME :
Angiotonin
CAS REGISTRY NUMBER :
1407-47-2
LAST UPDATED :
199012

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,43,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
10 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 58,406,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
20 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 8,525,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
20 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 8,525,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
200 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 8,525,1969

Related Compounds

  • Angiotensin I
  • angiotensin I
  • Angiotensin A
  • Angiotensin I
  • angiotensin iv
  • Angiotensin II
  • Ethanone, 2-bromo-1-(3-fluoro-2,6-dimethoxyphenyl)-
  • 2-[[[2-(Methylamino)ethyl]amino]methyl]phenol
  • 2-[(1-Ethenyl-2-ethynyl-2-methyl-3-buten-1-yl)oxy]tetrahydro-2H-pyran
  • 1,3-Benzodioxole-4-methanol, I+/--methyl-, 4-benzoate
  • 8-(2-Hydroxy-benzolylamino)octanoic acid ethylester
  • 2-[bis(Phenylmethyl)amino]-1-[4-hydroxy-3-(phenylmethoxy)phenyl]ethanone
  • 1-Butyryl-4-[3-(4-hydroxy-phenyl)-allyl]-piperazine
  • 3,3-Difluoro-3-(5-methyl-2-nitrophenyl)propan-1-ol
  • 1-(3-Fluoro-2-hydroxypropyl)piperidine-4-carbaldehyde
  • 1-(Benzyloxy)-3-(4-chloro-3-methylphenyl)propan-2-ol
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