(1S,3R,5Z,8ξ)-1,3-Bis{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-9, 10-secocholesta-5,10-dien-25-ol

Names

[ CAS No. ]:
140710-98-1

[ Name ]:
(1S,3R,5Z,8ξ)-1,3-Bis{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-9, 10-secocholesta-5,10-dien-25-ol

[Synonym ]:
MHED HYDROCHLORIDE
(1RS:2SR)-2-methylamino-1-(3-hydroxy-phenyl)-propanol-(1),hydrochloride
(1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-secocholesta-5(E),7(E),10(19)-trien-25-ol

Chemical & Physical Properties

[ Molecular Formula ]:
C39H74O3Si2

[ Molecular Weight ]:
647.17400

[ Exact Mass ]:
646.51800

[ PSA ]:
38.69000

[ LogP ]:
11.84360

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • METHYLMAGNESIUM BROMIDE
  • (3S)-1,3-Bis-O-tert-Butyldimethylsilyl 3-Hydroxy Vitamin D2 SO2 Adduct (Mixture of DiastereoMers)
  • (S)-2-((1R,3As,7Ar,E)-4-((E)-2-((3S,5R)-3,5-Bis(Tert-Butyldimethylsilyloxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propan-1-Ol

DownStream

  • Calcitriol
  • 5,6-trans-Calcitriol