N,N'-Bis(2-bromoethyl)phosphorodiamidic acid

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Names

[ CAS No. ]:
141025-16-3

[ Name ]:
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid

[Synonym ]:
N,N'-Bis(2-bromoethyl)phosphoric acid diamide
Phosphorodiamidic acid,N,N'-bis(2-bromoethyl)
HO-P(=O)(NHCH2CH2Br)2
bromoifosfamide mustard
Dibromo isophoramide mustard
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid

Chemical & Physical Properties

[ Density]:
1.934g/cm3

[ Boiling Point ]:
370.2ºC at 760mmHg

[ Molecular Formula ]:
C4H11Br2N2O2P

[ Molecular Weight ]:
309.92400

[ Flash Point ]:
177.7ºC

[ Exact Mass ]:
307.89200

[ PSA ]:
71.17000

[ LogP ]:
1.83760

[ Vapour Pressure ]:
1.69E-06mmHg at 25°C

[ Index of Refraction ]:
1.557

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TD2516500
CHEMICAL NAME :
Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-
CAS REGISTRY NUMBER :
141025-16-3
LAST UPDATED :
199212
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H11-Br2-N2-O2-P
MOLECULAR WEIGHT :
309.96

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
800 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 43,937,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Bromoethylamine hydrobromide

DownStream

Related Compounds

  • TH-302
  • N,N'-bis-(2-chloro-ethyl)-N-ethyl-phosphorodiamidic acid but-3-enyl ester
  • bis(2-hydroxyethylamino)phosphinic acid
  • 1,4-Cyclohexanedicarboxamide,N,N'-bis(2-chloroethyl)-, trans- (8CI)
  • Palifosfamide
  • O-(but-3-enyl) N,N'-bis(2-chloroethyl)phosphorodiamidate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-[1-(2-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutyl}acetyl)pyrrolidin-3-yl]acetic acid
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide