1-hydroxy-2-[4-(trifluoromethyl)phenyl]indole-3-carbonitrile

Names

[ CAS No. ]:
141135-81-1

[ Name ]:
1-hydroxy-2-[4-(trifluoromethyl)phenyl]indole-3-carbonitrile

[Synonym ]:
1-Hydroxy-3-cyano-2-(4-trifluoromethylphenyl)indole
1H-Indole-3-carbonitrile,1-hydroxy-2-[4-(trifluoromethyl)phenyl]

Chemical & Physical Properties

[ Molecular Formula ]:
C16H9F3N2O

[ Molecular Weight ]:
302.25100

[ Exact Mass ]:
302.06700

[ PSA ]:
48.95000

[ LogP ]:
4.43608

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 2-cyano-2-(2-nitrophenyl)acetate
  • Benzyl bromide
  • sodium carbonate
  • 1-(Bromomethyl)-4-(trifluoromethyl)benzene
  • Tetramethylguanidine

DownStream

Related Compounds

  • 5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole-3-carboxylic acid
  • (2R)-2-{5H,6H,8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl}pyrrolidine
  • N-methyl-N-{[5-(trifluoromethyl)furan-2-yl]methyl}hydroxylamine
  • (2R)-2-amino-2-[5-(trifluoromethyl)furan-2-yl]ethan-1-ol
  • (2S)-2-amino-2-[5-(trifluoromethyl)furan-2-yl]ethan-1-ol
  • (2S)-2-amino-2-[3-(trifluoromethyl)-1H-pyrazol-4-yl]ethan-1-ol
  • (2R)-2-amino-2-[3-(trifluoromethyl)-1H-pyrazol-4-yl]ethan-1-ol
  • N-methyl-N-{[3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}hydroxylamine
  • (1S)-1-[5-(Trifluoromethyl)(3-thienyl)]ethylamine
  • [1-(5-methoxy-1,3-dimethyl-1H-pyrazol-4-yl)cyclopropyl]methanamine