PX-12

Suppliers

Names

[ Name ]:
PX-12

[Synonym ]:
2-(butan-2-yldisulfanyl)-1H-imidazole
IV-2 compound
UNII:8PQ9CZ8BTJ
1-methylpropyl 2-imidazolyl disulfide
PX 12
1-methyl-1-propyl 2-imidazolyl disulfide
2-(sec-Butyldisulfanyl)-1H-imidazole
1-methylpropyl 2-mercaptoimidazolyl disulfide
2-[(1-Methylpropyl)dithio]-1H-imidazole
1H-Imidazole, 2-[(1-methylpropyl)dithio]-
PX-12

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
330.0±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₁₂N₂S₂

[ Molecular Weight ]:
188.314

[ Flash Point ]:
153.4±23.2 °C

[ Exact Mass ]:
188.044189

[ PSA ]:
79.28000

[ LogP ]:
3.40

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.590

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis.

Free Radic. Biol. Med. 82 , 29-41, (2015)

Microenvironmental hypoxia gives many tumor cells the capacity for drug resistance. Thioredoxin family members play critical roles in the regulation of cellular redox homeostasis in a stressed environ...

Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma.

Oncotarget 6 , 15410-24, (2015)

Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant accumulation of clonal plasma cells in the bone marrow. Despite recent advancement in anti-myeloma treatment, MM remai...

Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA.

PLoS ONE 8 , e77277, (2013)

To investigate the role of thioredoxin (TRX), a novel regulator of extracellular transglutaminase 2 (TG2), in celiac patients IgA (CD IgA) mediated TG2 enzymatic activation.TG2 enzymatic activity was ...

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