Endomorphin-2

Suppliers

Names

[ Name ]:
Endomorphin-2

[Synonym ]:
MFCD01321064
(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
H-Tyr-Pro-Phe-Phe-NH2
TYR-PRO-PHE-PHE-NH2
Tetrapeptide-15
Endomorphin-2

Chemical & Physical Properties

[ Density]:
1.292g/cm3

[ Boiling Point ]:
972.4ºC at 760mmHg

[ Melting Point ]:
130-131℃

[ Molecular Formula ]:
C₃₂H₃₇N₅O₅

[ Molecular Weight ]:
571.66700

[ Flash Point ]:
541.9ºC

[ Exact Mass ]:
571.27900

[ PSA ]:
167.85000

[ LogP ]:
3.31360

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Boc-L-phenylalanine
L-Phenylalanin amide hydrochloride
tert-butyl N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
H-Phe-Phe-NH2
Boc-L-Proline
Boc-Tyr-OH
Boc-Tyr(2,6-Cl2-Bzl)-OH
Fmoc-D-Tyr-OH

DownStream

Articles

Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications.

J. Med. Chem. 54 , 1462-72, (2011)

This study reports on new proteolytically stable, pharmacologically active endomorphin analogues, incorporating Dmt(1), Achc(2), pFPhe(4), or βMePhe(4) unnatural amino acids. Consistent with earlier r...

Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.

J. Med. Chem. 53 , 2383-9, (2010)

Substance P 1-7 (SP(1-7), H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH) is the major bioactive metabolite of substance P. The interest in this heptapeptide originates from the observation that it modulates, and i...

Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide.

Bioorg. Med. Chem. Lett. 17 , 2043-6, (2007)

Three dimethyl-L-tyrosine (Dmt) based peptide analogues were identified in a previous study as excellent agonists for the mu-opioid receptor showing very low K(i) values and good in vivo antinocicepti...

Endomorphin 2 TFA
(1,2-dimethylpyrrolidin-2-yl)methanol
N-[2-[3,4,5,6,7,8-Hexahydroazocin-1(2H)-yl]ethyl]phenylethylmalonamidic acid ethyl ester
3-(2-carboxy-5-chlorophenyl)-4-fluorobenzoic acid
Benzaldehyde,2,3,4,5,6-pentachloro-
3-(2-carboxy-5-fluorophenyl)-4-fluorobenzoic acid
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
(4-Bromophenyl)-(4-fluorophenyl)methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
5-(3-Bromopropoxy)-1-oxotetraline
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine