Sombrevin

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Names

[ CAS No. ]:
1421-14-3

[ Name ]:
Sombrevin

[Synonym ]:
Epontol
Sombrevin
Bayer 1420
Propantan
Fabontal
Fabantol
Propanidid
propanidide

Chemical & Physical Properties

[ Density]:
1.087g/cm3

[ Boiling Point ]:
459.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₇NO₅

[ Molecular Weight ]:
337.41100

[ Flash Point ]:
231.8ºC

[ Exact Mass ]:
337.18900

[ PSA ]:
65.07000

[ LogP ]:
2.43810

[ Vapour Pressure ]:
1.24E-08mmHg at 25°C

[ Index of Refraction ]:
1.503

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG9625000

CHEMICAL NAME :: Acetic acid, (4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)-, propyl ester

CAS REGISTRY NUMBER :: 1421-14-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C18-H27-N-O5

MOLECULAR WEIGHT :: 337.46

WISWESSER LINE NOTATION :: 3OV1R CO1 DO1VN2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Biochemical - Metabolism (Intermediary) - histamines (including liberation not immunochemical in origin)

REFERENCE :: BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year: 45,1097,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 81 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959- Volume(issue)/page/year: 17,21,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,845,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959- Volume(issue)/page/year: 17,21,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959- Volume(issue)/page/year: 17,21,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959- Volume(issue)/page/year: 17,21,1965 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 1200 mg/kg

SEX/DURATION :: female 1-60 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - physical

REFERENCE :: NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 64,2177,1964

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

2,5-Bis(4-aminophenyl)-4-amino-1,2,4-triazole
5,6-Dimethyl-7-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
3-Amino-4-methylcyclohexane-1-carboxylic acid
5-Amino-2-ethylcyclohexane-1-carboxylic acid
9-(2,4-dichlorophenyl)-6,7-dimethoxy-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one
Clofazimine hydrogen-sulfate
Ethyl 2-furanyl diketone
Methyl 3-{2-[(3-phenylpropanoyl)amino]phenoxy}-2-thiophenecarboxylate
1h-Pyrrolo[2,3-c]pyridine-3-carboxylic acid,2,3-dihydro-2-hydroxy-,ethyl ester
2-(3-thienyl)-1H-imidazole

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