L-3,4-Dihydroxyphenylalanine Methyl ester hydrochloride

Suppliers

Names

[ Name ]:
L-3,4-Dihydroxyphenylalanine Methyl ester hydrochloride

[Synonym ]:
L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride
MFCD00038958
L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride (1:1)
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate,hydrochloride
Methyl 3-hydroxy-L-tyrosinate hydrochloride (1:1)
(S)-Methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate hydrochloride
Methyl L-DOPA hydrochloride
methyldopa hydrochloride

Chemical & Physical Properties

[ Density]:
1.322g/cm3

[ Boiling Point ]:
384.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₄ClNO₄

[ Molecular Weight ]:
247.676

[ Flash Point ]:
186.3ºC

[ Exact Mass ]:
247.061142

[ PSA ]:
92.78000

[ LogP ]:
1.64290

[ Vapour Pressure ]:
1.86E-06mmHg at 25°C

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Striatal astrocytes act as a reservoir for L-DOPA.

PLoS ONE 9(9) , e106362, (2014)

L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transport...

L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.

J. Neurosci. Res. 92(12) , 1733-45, (2014)

L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is the most common complication of standard L-DOPA therapy for Parkinson's disease experienced by most parkinsonian patients. LID is asso...

Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental L-DOPA-induced dyskinesia.

Synapse 68(8) , 332-43, (2014)

l-3,4-Dihydroxyphenylalanine (L-DOPA) is the most widely used drug for the treatment of Parkinson's disease. Unfortunately, chronic administration of this dopamine precursor causes L-DOPA-induced dysk...