2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one

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Names

[ CAS No. ]:
142217-81-0

[ Name ]:
2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one

[Synonym ]:
Entecavir InterMediate VIII IsoMer
3',5'-Di-O-benzyl Entecavir
Entecavir-9
2-Amino-9-{(1S,3R,4S)-4-(benzyloxy)-3-[(benzyloxy)methyl]-2-methylenecyclopentyl}-1,9-dihydro-6H-purin-6-one
6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-
Entecavir E8
Entecavir InterMediate N-1
Entecavir Impurity 16

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C26H27N5O3

[ Molecular Weight ]:
457.524

[ Exact Mass ]:
457.211395

[ PSA ]:
108.05000

[ LogP ]:
3.97

[ Index of Refraction ]:
1.679

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
  • Benzyl chloromethyl ether
  • (benzyloxymethyl)cyclopenta-2,4-diene
  • (1S,2R,3S,5R)-3-phenylmethoxy-2-(phenylmethoxymethyl)-6-oxabicyclo[3.1.0]hexane
  • (1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol
  • (1S,2R)-2-[(Benzyloxy)methyl]-3-cyclopenten-1-ol
  • 5-[2-[[(4-Methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]cyclopentanol
  • (2R,3S,5S)-5-[2-[[(4-methoxyphenyl)-diphenylmethyl]amino]-6-phenylmethoxypurin-9-yl]-3-phenylmethoxy-2-(phenylmethoxymethyl)cyclopentan-1-one
  • (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol
  • SODIUM CYCLOPENTADIENIDE

DownStream

  • Entecavir

Related Compounds

  • 2-Chloro-3-(propan-2-yloxy)benzoic acid
  • 3-[4-(Benzyloxy)phenyl]pyrrolidine
  • 1-(5-Fluoropyridin-3-yl)ethanamine;hydrochloride
  • tert-butyl N-[1-[(3R)-pyrrolidin-3-yl]cyclopropyl]carbamate;hemi(oxalic acid)
  • 5-[(Z)-[(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)hydrazinylidene]methyl]benzene-1,2,3-triol
  • (S)-1-(4-(Trifluoromethyl)pyridin-2-yl)ethanamine hydrochloride
  • (R)-1-(4-Chloropyridin-2-yl)ethanamine hydrochloride
  • 1-O'-tert-butyl 3-O'-ethyl (5R)-2-chlorospiro[7,8-dihydro-6H-quinoline-5,4'-pyrrolidine]-1',3'-dicarboxylate
  • 6-Methyl-2-piperazinone hydrochloride
  • methyl 2-{5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl}acetate
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