protionamide

Names

[ Name ]:
protionamide

[Synonym ]:
2-propylpyridine-4-carbothioamide
EINECS 238-093-7
protionamide
2-Propyl-4-pyridinecarbothioamide
Propylthioisonicotinamide
4-Pyridinecarbothioamide, 2-propyl-
Prothionamide
MFCD00464119

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
310.4±44.0 °C at 760 mmHg

[ Melting Point ]:
140ºC

[ Molecular Formula ]:
C₉H₁₂N₂S

[ Molecular Weight ]:
180.270

[ Flash Point ]:
141.5±28.4 °C

[ Exact Mass ]:
180.072113

[ PSA ]:
71.00000

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
Refrigerator

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS0650000

CHEMICAL NAME :: Isonicotinamide, 2-propylthio-

CAS REGISTRY NUMBER :: 14222-60-7

BEILSTEIN REFERENCE NO. :: 0118164

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H12-N2-S

MOLECULAR WEIGHT :: 180.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,471,1975

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Propylisonicotinonitrile
2-propylisonicotinamide
2-chloro-6-propyl-isonicotinic acid ethyl ester

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.

Ann. Allergy Asthma Immunol. 110(2) , 118-9, (2013)

Acceptability of thioamides. II. Prothionamide.

J. Postgrad. Med. 23(4) , 181-5, (1977)

Molecular structure and vibrational spectroscopic studies of prothionamide by density functional theory.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 152 , 262-71, (2016)

Prothionamide (PTH) is the secondary drug used against Mycobacterium tuberculosis bacteria and leprosy. The aim of this work was to investigate the potential energy surface map, anharmonic and harmoni...

Protionamide Sulfoxide
Protionamide Sulfoxide
Protionamide-d5 Sulfoxide
tert-butyl N-{2-[2-(2-nitrophenyl)ethyl]phenyl}carbamate
Tert-butyl 4-[cyclohexyl(methyl)sulfamoyl]piperazine-1-carboxylate
tert-butyl N-(3-bromo-5-fluoro-2-nitrophenyl)carbamate
tert-butyl N-(5-nitroisoquinolin-1-yl)carbamate
2-({[(Benzyloxy)carbonyl]({1-[(tert-butoxy)carbonyl]azetidin-3-yl})amino}methyl)furan-3-carboxylic acid
1-(2-Bromophenyl)-3-(thiophen-3-yl)prop-2-yn-1-one
benzyl N-(5-cyanopyridin-2-yl)-N-methylcarbamate
tert-butyl N-{6-cyano-2-methylpyrazolo[1,5-a]pyrimidin-7-yl}carbamate
tert-butyl 4-[4-(pyridin-2-yl)piperazine-1-carbonyl]-1H-pyrazole-1-carboxylate
tert-butyl N-(3,5-dicyanopyridin-2-yl)carbamate

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.