Adefovir Dipivoxil

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
641.0±65.0 °C at 760 mmHg

[ Melting Point ]:
98-102ºC

[ Molecular Formula ]:
C₂₀H₃₂N₅O₈P

[ Molecular Weight ]:
501.470

[ Flash Point ]:
341.5±34.3 °C

[ Exact Mass ]:
501.198853

[ PSA ]:
176.79000

[ LogP ]:
2.45

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
−20°C

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

Click to get detail synthetic route

Precursor

DownStream

Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.

J. Pharm. Sci. 104(3) , 1056-64, (2015)

The physical form of anhydrous adefovir dipivoxil (AD), obtained following the dehydration of AD dihydrate, was governed by the kinetics of water removal. The rate and extent of water removal followin...

De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.

World J. Gastroenterol. 19(37) , 6278-83, (2013)

To compare efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for hepatitis B virus (HBV)-related decompensated liver cirrhosis.A total...

Discovering novel direct acting antiviral agents for HBV using in silico screening.

Biochem. Biophys. Res. Commun. 456(1) , 20-8, (2015)

The treatments for chronic hepatitis B (CHB) are interferon and nucleoside analogues reverse transcriptase (RT) inhibitors. Because both treatments are less than ideal, we conducted to identify novel ...

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