Adefovir Dipivoxil

Suppliers

Names

[ CAS No. ]:
142340-99-6

[ Name ]:
Adefovir Dipivoxil

[Synonym ]:
9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine
BIS POM PMEA
ADEFOVIR PIVOXIL
Adefovir Dipivoxil
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine
Hepsera
ADEFOVIR DIPVOXIL
Preveon
MFCD00869897
EINECS 200-001-8
ADEFOVIR DIPIVOLIX
Adefovir Dipivoxyl
Adefovir Dipivoxi
Adefovir Dipivoxl
Adefovir Impurity 3

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
641.0±65.0 °C at 760 mmHg

[ Melting Point ]:
98-102ºC

[ Molecular Formula ]:
C20H32N5O8P

[ Molecular Weight ]:
501.470

[ Flash Point ]:
341.5±34.3 °C

[ Exact Mass ]:
501.198853

[ PSA ]:
176.79000

[ LogP ]:
2.45

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Chloromethyl pivalate
  • Adefovir
  • 9-(2-Diisopanoxyphosphonylmethoxyethyl)adenine
  • Iodomethyl pivalate
  • 6H-Purin-6-imine, 1,7-dihydro- (9CI)
  • 2-(6-amino-9H-purin-9-yl)ethanol

DownStream

Articles

Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.

J. Pharm. Sci. 104(3) , 1056-64, (2015)

The physical form of anhydrous adefovir dipivoxil (AD), obtained following the dehydration of AD dihydrate, was governed by the kinetics of water removal. The rate and extent of water removal followin...

De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.

World J. Gastroenterol. 19(37) , 6278-83, (2013)

To compare efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for hepatitis B virus (HBV)-related decompensated liver cirrhosis.A total...

Discovering novel direct acting antiviral agents for HBV using in silico screening.

Biochem. Biophys. Res. Commun. 456(1) , 20-8, (2015)

The treatments for chronic hepatitis B (CHB) are interferon and nucleoside analogues reverse transcriptase (RT) inhibitors. Because both treatments are less than ideal, we conducted to identify novel ...


More Articles

Related Compounds

  • Adefovir Dipivoxil Impurity 23
  • Adefovir Dipivoxil Impurity 20
  • Adefovir-d4 Diphosphate triethylamine salt
  • Adefovir iMpurity
  • Adefovir-d4 phosphate triethylamine salt
  • Adefovir-d4
  • N-[1-(2-Fluoro-4-methoxyphenyl)ethyl]-3-methyl-1,2,4-oxadiazole-5-methanamine
  • But-2-ene-2-sulfonamide
  • 6-bromo-2-(chloromethyl)-3H-imidazo[4,5-b]pyridine hydrochloride
  • 6'-bromo-4-ethoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
  • N-(3,5-dimethylphenyl)-2-(3-ethyl-4-oxo-thieno[3,2-d]pyrimidin-2-yl)sulfanyl-acetamide
  • N,N-dimethyl-4-[(3-methylsulfonylpropylamino)methyl]aniline
  • ethyl 2-[[2-(1-oxophthalazin-2-yl)acetyl]amino]thiazole-4-carboxylate
  • 4-(2,2,2-Trifluoroethoxy)-3-(trifluoromethyl)aniline
  • N-(3-chlorobenzyl)-2-(3-(furan-2-yl)-6-oxopyridazin-1(6H)-yl)acetamide
  • N-[(2Z)-4-tert-butyl-1,3-thiazol-2(3H)-ylidene]-2-[6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetamide
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