2,3-bis(4-hydroxyphenyl)propionitrile

Suppliers

Names

[ CAS No. ]:
1428-67-7

[ Name ]:
2,3-bis(4-hydroxyphenyl)propionitrile

[Synonym ]:
2,3-bis(4-hydroxyphenyl)propionitrile
DPN Diarylpropionitrile SC-4473
2,3-Bis(4-hydroxyphenyl)propanenitrile
Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-
DPN

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
449.4±35.0 °C at 760 mmHg

[ Melting Point ]:
203°C

[ Molecular Formula ]:
C15H13NO2

[ Molecular Weight ]:
239.269

[ Flash Point ]:
225.6±25.9 °C

[ Exact Mass ]:
239.094635

[ PSA ]:
64.25000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.640

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UG0900000
CHEMICAL NAME :
Propionitrile, 2,3-bis(p-hydroxyphenyl)
CAS REGISTRY NUMBER :
1428-67-7
BEILSTEIN REFERENCE NO. :
3337109
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H13-N-O2
MOLECULAR WEIGHT :
239.29
WISWESSER LINE NOTATION :
QR DYCN&1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,176,1954

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319-H400

[ Precautionary Statements ]:
P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,3-bis(4-methoxyphenyl)propanenitrile
  • 1-bromomethyl-4-methoxybenzene
  • (4-Methoxyphenyl)acetonitrile

DownStream

Articles

A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.

Toxicol. Appl. Pharmacol. 283(3) , 187-97, (2015)

Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selecti...

Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons.

Endocrinology 156 , 2162-73, (2015)

The neuropeptide kisspeptin is essential for sexual maturation and reproductive function. In particular, kisspeptin-expressing neurons in the anterior rostral periventricular area of the third ventric...

Methyltransferase-like 17 physically and functionally interacts with estrogen receptors.

IUBMB Life 67 , 861-8, (2016)

Estrogen exerts its physiological and pathological functions through two estrogen receptors (ERs), ERα and ERβ, which act as transcription factors. Coregulators, including coactivators and corepressor...


More Articles

Related Compounds

  • 2,3-bis(4-hydroxyphenyl)but-2-enedinitrile
  • 2,3-bis(4-hydroxyphenyl)cyclopent-2-en-1-one
  • 2,3-bis(4-hydroxyphenyl)propane-1,2-diol
  • 2,3-bis(4-hydroxyphenyl)pentanenitrile
  • 2,3-bis(4-hydroxyphenyl)-1,3a-dihydropyrazolo[1,5-a]pyrimidin-6-ol
  • 2,3-bis(4-hydroxyphenyl)prop-2-enenitrile