(r)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1h-indole

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Names

[ CAS No. ]:
143322-56-9

[ Name ]:
(r)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1h-indole

[Synonym ]:
(R)-2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester
InterMediate of Eletriptan
benzyl (2R)-2-[(5-bromo-1H-indole-3-yl)carbonyl]pyrrolidine-1-carboxylate
(R)-2-(5-bomo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester
(R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylcarbonyl)-5-bromo-1H-indole
(R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole
(R)-2-[(5-Bromo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic acid benzyl ester
(2R)-2-[(5-BroMo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic Acid PhenylMethyl Ester
(R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate
3-(N-benzyloxycarbonylpyrrolidin-2R-ylcarbonyl)-5-bromo-1H-indole

Chemical & Physical Properties

[ Density]:
1.505

[ Boiling Point ]:
605ºC at 760 mmHg

[ Molecular Formula ]:
C21H19BrN2O3

[ Molecular Weight ]:
427.29100

[ Flash Point ]:
319.7ºC

[ Exact Mass ]:
426.05800

[ PSA ]:
62.40000

[ LogP ]:
4.85220

[ Vapour Pressure ]:
1.38E-14mmHg at 25°C

[ Index of Refraction ]:
1.678

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Bromoindole
  • (R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride
  • SodiuM bicarbonate
  • Methylmagnesium chloride
  • Oxalyl chloride
  • ETHYLMAGNESIUM BROMIDE
  • N-CBZ-D-Proline

DownStream

  • 1-[5-bromo-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]indol-1-yl]ethanone
  • (R)-5-Bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole
  • Eletriptan HBr

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%