Hydroquinidine

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Names

[ CAS No. ]:
1435-55-8

[ Name ]:
Hydroquinidine

[Synonym ]:
EINECS 215-862-5
HYDROQUINIDINE
(9S)-6'-Methoxy-10,11-dihydrocinchonan-9-ol
MFCD00135599
(+)-Dihydroquinidine
(9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-
dihydroquinidine
hydroconchinine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
498.4±30.0 °C at 760 mmHg

[ Melting Point ]:
169-170 ºC

[ Molecular Formula ]:
C20H26N2O2

[ Molecular Weight ]:
326.433

[ Flash Point ]:
255.2±24.6 °C

[ Exact Mass ]:
326.199432

[ PSA ]:
45.59000

[ LogP ]:
3.77

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.626

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MX3016000
CHEMICAL NAME :
Hydroquinidine
CAS REGISTRY NUMBER :
1435-55-8
LAST UPDATED :
199607
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H26-N2-O2
MOLECULAR WEIGHT :
326.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
12 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - headache Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 18,659,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 84,184,1945

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
36/37-36

[ RIDADR ]:
UN 1544

[ WGK Germany ]:
3

[ RTECS ]:
MX3016000

[ Packaging Group ]:
III

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Quinidine

DownStream

  • 3,4-diethylpyridine
  • 6-Methoxylepidine
  • Quininic acid
  • HYDROQUINIDINE 4-CHLOROBENZOATE
  • (DHQD)2PHAL
  • HYDROQUINIDINE 4-METHYL-2-QUINOLYL ETHER

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • Dihydroquinidine
  • Hydroquinidine HCl
  • hydroquinidine gluconate
  • HYDROQUINIDINE 4-CHLOROBENZOATE
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  • 1,4-Bis(dihydroquinidine)phthalazine
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