Triapine

Suppliers

Names

[ Name ]:
Triapine

[Synonym ]:
2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide
3-Aminopyridine-2-carboxaldehyde thiosemicarbazone 3-AP PAN-811
(2E)-2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
436.0±55.0 °C at 760 mmHg

[ Melting Point ]:
234°C(lit.)

[ Molecular Formula ]:
C₇H₉N₅S

[ Molecular Weight ]:
195.245

[ Flash Point ]:
217.5±31.5 °C

[ Exact Mass ]:
195.057861

[ PSA ]:
125.95000

[ LogP ]:
0.98

[ Appearance of Characters ]:
white to light brown

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.720

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble10Meq/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Methyl-3-nitropyridine
3-nitropyridine-2-carbaldehyde
Thiosemicarbazide
TERT-BUTYL (5-FORMYLPYRIDIN-2-YL)CARBAMATE
2-Chlorpyridin-3-amin
2-Chloro-3-nitropyridine
N,N-dimethyl-2-(3-nitropyridin-2-yl)ethenamine

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Trypanotoxic activity of thiosemicarbazone iron chelators.

Exp. Parasitol. 150 , 7-12, (2015)

Only a few drugs are available for treating sleeping sickness and nagana disease; parasitic infections caused by protozoans of the genus Trypanosoma in sub-Saharan Africa. There is an urgent need for ...

Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes.

Antioxid. Redox Signal. 18(8) , 956-72, (2013)

Despite advances made in the treatment of cancer, a significant number of patients succumb to this disease every year. Hence, there is a great need to develop new anticancer agents.Emerging data show ...

Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.

Cancer Res. 75 , 2863-74, (2015)

Generalized strategies to improve breast cancer treatment remain of interest to develop. In this study, we offer preclinical evidence of an important metabolic mechanism underlying the antitumor activ...

Triapine
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4-(10H-Phenoxazin-10-yl)-N,N-diphenylaniline
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1-[1-(Difluoromethyl)-1H-pyrazol-5-yl]ethanone

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