(R)-3-Isopropylpiperazine-2,5-dione

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Names

[ Name ]:
(R)-3-Isopropylpiperazine-2,5-dione

[Synonym ]:
2,5-Piperazinedione, 3-(1-methylethyl)-, (3R)-
(R)-3-Isopropyl-2,5-piperizinedione
(3R)-3-isopropylpiperazine-2,5-dione
(R)-(-)-3-Isopropyl-2,5-piperazinedione
(3R)-3-Isopropyl-2,5-piperazinedione
(R)-3-Isopropylpiperazine-2,5-dione
MFCD00210060

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
445.7±38.0 °C at 760 mmHg

[ Melting Point ]:
258-262 â„ƒ(lit.)

[ Molecular Formula ]:
C₇H₁₂N₂O₂

[ Molecular Weight ]:
156.182

[ Flash Point ]:
216.5±26.9 °C

[ Exact Mass ]:
156.089874

[ PSA ]:
58.20000

[ LogP ]:
-1.19

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.459

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38-20/21/22

[ Safety Phrases ]:
22-24/25-36/37/39-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

D-valine N-carboxy anhydride
Ethyl glycinate
Boc-D-Val-Gly-OEt
methyl N-(tert-butoxycarbonyl)-D-valyl-glycinate
Z-D-Val-OH
H-D-Val-OH
Boc-D-Valine
N-benzyloxycarbonyl-(2R)-valinylglycine methyl ester

DownStream

(R)-2-Isopropylpiperazine dihydrochloride
(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
(r)-2,5-dihydro-3,6-diethoxy-2-isopropylPyrazine
(R)-1-BENZYL-3-ISOPROPYLPIPERAZINE-2,5-DIONE

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Schöllkopf, U. et al.

Angew. Chem. Int. Ed. Engl. 20 , 798, (1981)

Rose, J.E. et al.

J. Chem. Soc. Perkin Trans. I , 1563, (1992)