2-Acetyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid

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Names

[ CAS No. ]:
143767-54-8

[ Name ]:
2-Acetyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid

[Synonym ]:
2-acetyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.283g/cm3

[ Boiling Point ]:
465.2ºC at 760 mmHg

[ Melting Point ]:
170-171 ºC

[ Molecular Formula ]:
C12H13NO3

[ Molecular Weight ]:
219.23700

[ Flash Point ]:
235.1ºC

[ Exact Mass ]:
219.09000

[ PSA ]:
57.61000

[ LogP ]:
0.98230

[ Vapour Pressure ]:
1.87E-09mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Water Solubility ]:
Slightly soluble (2.9 g/L) (25 ºC)

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • h-dl-tic-oh
  • Acetyl chloride
  • [(2R)-pyrrolidin-2-yl]methanol,hydrochloride
  • o-Xylylene dichloride
  • α,α′-dibromo-o-xylene

DownStream

  • H-Tic-OH
  • 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
  • D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
  • 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • dimethyl 3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-dicarboxylate

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-benzyl-2-(2-(cyclohexylamino)-2-oxoethyl)-N-isopropyl-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
  • N-isobutyl-2-(2-(isopropylamino)-2-oxoethyl)-4-(4-methylbenzyl)-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
  • 2-((5-(3-bromophenyl)oxazol-2-yl)thio)-N-(thiophen-2-ylmethyl)propanamide
  • 2-(Pyrrolidin-3-yl)-2H-1,2,3-triazole
  • 2-((5-(3,4-dimethylphenyl)oxazol-2-yl)thio)-N-(naphthalen-1-yl)acetamide
  • 2-((5-(3-bromophenyl)oxazol-2-yl)thio)-N-(o-tolyl)propanamide
  • N-(sec-butyl)-4-(3-methylbutyl)-2-{2-[(4-methylphenyl)amino]-2-oxoethyl}-1,5-dioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
  • 2-((5-(3-bromophenyl)oxazol-2-yl)thio)-N-(4-fluorobenzyl)propanamide
  • 2-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)-N,4-diisobutyl-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
  • N-(sec-butyl)-4-(3-methylbutyl)-2-{2-[(2-methylphenyl)amino]-2-oxoethyl}-1,5-dioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide