MJN110

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Names

[ CAS No. ]:
1438416-21-7

[ Name ]:
MJN110

[Synonym ]:
MJN110
2,5-dioxopyrrolidin-1-yl 4-[bis(4-chlorophenyl)methyl]piperazine-1-carboxylate

Chemical & Physical Properties

[ Density]:
1.47±0.1 g/cm3

[ Boiling Point ]:
561.5±60.0 °C

[ Molecular Formula ]:
C₂₂H₂₁Cl₂N₃O₄

[ Molecular Weight ]:
462.32600

[ Exact Mass ]:
461.09100

[ PSA ]:
70.16000

[ LogP ]:
3.71470

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
22-50/53

[ Safety Phrases ]:
26-60-61

[ RIDADR ]:
NONH for all modes of transport

Articles

Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus.

Psychopharmacol. Ser. 232(3) , 583-93, (2015)

To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting.We evaluated the effectiveness of the potent selective monoacylglycerol lipase (MA...

Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.

ACS Chem. Biol. , (2013)

Serine hydrolases are one of the largest and most diverse enzyme classes in Nature. Inhibitors of serine hydrolases are used to treat many diseases, including obesity, diabetes, cognitive dementia, an...

Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors.

ACS Chem. Neurosci. 4(9) , 1322-32, (2013)

Monoacylglycerol lipase (MAGL) is a principal metabolic enzyme responsible for hydrolyzing the endogenous cannabinoid (endocannabinoid) 2-arachidonoylglycerol (2-AG). Selective inhibitors of MAGL offe...