(R)-1-Boc-3-Hydroxypiperidine

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Names

[ CAS No. ]:
143900-43-0

[ Name ]:
(R)-1-Boc-3-Hydroxypiperidine

[Synonym ]:
R-1-Boc-3-hydroxypiperidine
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3R)-
MFCD06659042
2-Methyl-2-propanyl 3-hydroxy-1-piperidinecarboxylate
(R)-1-Boc-3-hydroxypiperidine
tert-Butyl-(3R)-3-hydroxypiperidin-1-carboxylat
(R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate
(R)-1-Boc-3-piperidinol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
292.3±33.0 °C at 760 mmHg

[ Melting Point ]:
43-50ºC

[ Molecular Formula ]:
C10H19NO3

[ Molecular Weight ]:
201.26

[ Flash Point ]:
130.6±25.4 °C

[ Exact Mass ]:
201.136490

[ PSA ]:
49.77000

[ LogP ]:
0.49

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.496

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S45-S36-S37-S39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (3R)-3-Piperidinol
  • Di-tert-butyl dicarbonate
  • 1-Boc-3-hydroxypiperidine
  • DIEA
  • 4-methylmorpholine
  • Methyl Pyrrolidine-2-Carboxylate
  • (S)-(-)-1-BENZYL-2-PYRROLIDINEMETHANOL
  • (R)-Methyl 1-benzylpyrrolidine-2-carboxylate
  • (3S)-1-Benzyl-3-piperidinol
  • H-D-Pro-OH

DownStream

  • 1-Boc-3-Piperidinone
  • (S)-3-Amino-1-N-Boc-piperidine
  • (3R)-1-methylpiperidin-3-ol
  • (R)-1-N-BOC-3-METHANESULFONYLOXYPIPERIDINE

Related Compounds

  • (R)-1-Boc-3-(2-Oxoethyl)Piperidine
  • (R)-1-Boc-3-(aminomethyl)pyrrolidine
  • (R)-1-BOC-3-BENZYLPIPERAZINE
  • (R)-1-Boc-3-Fluoropyrrolidine
  • (R)-1-Boc-3-hydroxymethylpiperazine
  • (R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE
  • 2-Amino-5-chloro-4-(difluoromethyl)nicotinaldehyde
  • 2-Bromo-4-(bromomethyl)-6-(difluoromethyl)nicotinonitrile
  • 2,4-Difluoro-5-(2-(trifluoromethyl)phenyl)pyrimidine
  • 2-Chloro-3-(difluoromethyl)-5-iodopyridine
  • 2-Chloro-5-(difluoromethyl)-6-fluoro-3-nitropyridine
  • 2-Chloro-4-(difluoromethyl)-5-hydroxypyridine-3-sulfonamide
  • 2-Chloro-3-phenyl-4-pyridineacetic acid
  • 2-Bromo-6-(difluoromethyl)-4-fluoropyridine
  • 6-Bromo-5-(difluoromethyl)-4-nitropyridin-3-ol
  • 2,5-Dibromo-3-(trifluoromethoxy)pyridine
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