Piclamilast

Suppliers

Names

[ CAS No. ]:
144035-83-6

[ Name ]:
Piclamilast

[Synonym ]:
3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide
3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
Piclamilast
3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
Cpodpmb
Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
447.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H18Cl2N2O3

[ Molecular Weight ]:
381.253

[ Flash Point ]:
224.6±28.7 °C

[ Exact Mass ]:
380.069458

[ PSA ]:
63.68000

[ LogP ]:
5.25

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.626

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Amino-3,5-dichloropyridine
  • 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOYL CHLORIDE
  • 3-(Cyclopentyloxy)-4-methoxybenzaldehyde
  • 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOIC ACID
  • Isovanillin
  • Bromocyclopentane

DownStream

Articles

Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways.

J. Biol. Chem. 279(40) , 42026-40, (2004)

Inhibition of phosphodiesterase IV by N-(3,5-dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide (piclamilast) enhances the myeloid differentiation induced by all-trans-retinoic acid (ATRA), retin...

Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors.

Clin. Exp. Immunol. 128(3) , 460-6, (2002)

Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has confounded an accurate assessment of PDE7 function in such cells. In order...

The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion.

J. Cell Physiol. 226(8) , 1970-80, (2011)

Lung fibroblast proliferation and differentiation into myofibroblasts are pathological key events during development of lung fibrosis. Cyclic nucleotide signaling is described as a negative modulator ...


More Articles

Related Compounds

  • Piclamilast
  • Piclamilast
  • 3,6,10-Trimethyl-7,8,9,10-tetrahydrobenzo[8]annulen-2-ol
  • 2-(6-Bromopyridin-2-yl)-2-methoxypropan-1-amine
  • 4-(3,4-dihydro-2H-pyran-5-yl)-1,3-thiazol-2-amine
  • 4-(5-Bromopyrimidin-2-yl)-1,3-thiazol-2-amine
  • tert-butyl N-{3-amino-2-[2-(trifluoromethyl)phenyl]propyl}carbamate
  • 2-(6-Chloro-2-methoxypyridin-3-yl)-2,2-difluoroacetic acid
  • 2-[1-(6-Chloropyridin-3-yl)cyclopropyl]-2-hydroxyacetic acid
  • 1-(2,3-dihydro-1H-inden-1-yl)cyclopentane-1-carboxylic acid
  • 1-(6-Chloro-5-methylpyridin-3-yl)-2,2-dimethylcyclopropane-1-carboxylic acid
  • 3-(1-Bromo-2-methylpropan-2-yl)-2,5-dimethylfuran
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