Piclamilast

Suppliers

Names

[ CAS No. ]:
144035-83-6

[ Name ]:
Piclamilast

[Synonym ]:
3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide
3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
Piclamilast
3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
Cpodpmb
Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
447.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H18Cl2N2O3

[ Molecular Weight ]:
381.253

[ Flash Point ]:
224.6±28.7 °C

[ Exact Mass ]:
380.069458

[ PSA ]:
63.68000

[ LogP ]:
5.25

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.626

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Amino-3,5-dichloropyridine
  • 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOYL CHLORIDE
  • 3-(Cyclopentyloxy)-4-methoxybenzaldehyde
  • 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOIC ACID
  • Isovanillin
  • Bromocyclopentane

DownStream

Articles

Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways.

J. Biol. Chem. 279(40) , 42026-40, (2004)

Inhibition of phosphodiesterase IV by N-(3,5-dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide (piclamilast) enhances the myeloid differentiation induced by all-trans-retinoic acid (ATRA), retin...

Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors.

Clin. Exp. Immunol. 128(3) , 460-6, (2002)

Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has confounded an accurate assessment of PDE7 function in such cells. In order...

The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion.

J. Cell Physiol. 226(8) , 1970-80, (2011)

Lung fibroblast proliferation and differentiation into myofibroblasts are pathological key events during development of lung fibrosis. Cyclic nucleotide signaling is described as a negative modulator ...


More Articles

Related Compounds

  • Piclamilast
  • Piclamilast
  • 1,3,4-Oxadiazole-2-butanoic acid, 5-(3,5-difluorophenyl)-I(2)-methyl-
  • 3,5-Dihydroxy-4,4-dimethylpentanoic acid
  • 4-(Tetrahydro-2H-pyran-3-yl)aniline
  • 2-(2,3,4-Trifluorophenyl)aniline
  • Methyl[2-(2,3,4-trifluorophenyl)ethyl]amine
  • (1'-Methyl-[1,4'-bipiperidin]-2-yl)methanamine
  • 6-Ethoxy-1H-indazol-3-ylamine
  • 3,5-Dichloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one
  • 1-[(1-Methoxypropan-2-yl)amino]propan-2-ol
  • 6-fluoro-7-iodo-1H-indole-2,3-dione
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