4'-Chlorodiazepam

Suppliers

Names

[ CAS No. ]:
14439-61-3

[ Name ]:
4'-Chlorodiazepam

[Synonym ]:
Chlorodiazepam
4'-Chlorodiazepam
7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
Ro-5-4864
7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
517.1ºC at 760mmHg

[ Melting Point ]:
160-163ºC

[ Molecular Formula ]:
C16H12Cl2N2O

[ Molecular Weight ]:
319.18500

[ Flash Point ]:
266.6ºC

[ Exact Mass ]:
318.03300

[ PSA ]:
32.67000

[ LogP ]:
3.30780

[ Vapour Pressure ]:
8.43E-11mmHg at 25°C

[ Index of Refraction ]:
1.647

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF0500000
CHEMICAL NAME :
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-
CAS REGISTRY NUMBER :
14439-61-3
BEILSTEIN REFERENCE NO. :
0685202
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H12-Cl2-N2-O
MOLECULAR WEIGHT :
319.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Cells - not otherwise specified
DOSE/DURATION :
10 nmol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 49,115,1990

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22

[ RIDADR ]:
UN 2811

[ RTECS ]:
DF0500000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 7-chloro-1,3-dihydro-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one
  • methyl iodide
  • 5-Chloro-3-(4-chlorophenyl)-2,1-benzoxazole
  • 5,4'-dichloro-2-methylaminobenzophenone
  • 4-Chloronitrobenzene
  • 4-Chlorobenzyl cyanide

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.

J. Med. Chem. 49 , 5845-8, (2006)

Cultured rat astrocytes and C6 rat glioma were used as a differential screen for a variety of 1,2,3,4-tetrahydroisoquinoline (THI) derivatives. Compound 1 [1-(biphenyl-4-ylmethyl)-1,2,3,4-tetrahydrois...

Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.

Life Sci. 92(6-7) , 345-51, (2013)

This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity.Gene expression analyse...

Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.

Biochem. Pharmacol. 97 , 99-110, (2015)

As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the developm...


More Articles

Related Compounds

  • desmethyl-4'-chlorodiazepam
  • 4'-(1,3-DIOXOLAN-2-YL)-3-METHOXYBENZOPHENONE
  • 4'-Amylphenyl-4-methoxybenzoate
  • 4'-O-Methylstephavanine
  • 4'-Benzofuran-2-yl-2,3,4,5,4',5'-hexahydro-3'H-[1,2']bipyrrolyl; hydrochloride
  • 4'-O-tert-Butyldimethylsilyl Genistein