7-chloro-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Names

[ CAS No. ]:
144485-79-0

[ Name ]:
7-chloro-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
490ºC at 760mmHg

[ Molecular Formula ]:
C12H8ClN3O2

[ Molecular Weight ]:
261.66400

[ Flash Point ]:
250.1ºC

[ Exact Mass ]:
261.03100

[ PSA ]:
60.92000

[ LogP ]:
2.33550

[ Vapour Pressure ]:
9.53E-10mmHg at 25°C

[ Index of Refraction ]:
1.702

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2806010
CHEMICAL NAME :
4(3H)-Quinazolinone, 7-chloro-3-(3-methyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
144485-79-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H8-Cl-N3-O2
MOLECULAR WEIGHT :
261.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-chloro-2-nitrobenzoyl chloride
  • 2-amino-4-chloro-N-(3-methyl-1,2-oxazol-5-yl)benzamide
  • Triethyl orthoformate

DownStream

Related Compounds

  • tert-butyl N-[5-(2-aminoethoxy)-2-chlorophenyl]carbamate
  • tert-butyl N-[1-(4-methylthiophen-3-yl)-2-oxoethyl]carbamate
  • tert-butyl N-(1-oxo-2-{pyrazolo[1,5-a]pyrimidin-2-yl}propan-2-yl)carbamate
  • tert-butyl N-{3-[2-(piperazin-1-yl)ethyl]oxolan-3-yl}carbamate
  • tert-butyl N-(1-{bicyclo[2.2.1]heptan-2-yl}-2-oxoethyl)-N-methylcarbamate
  • tert-butyl N-{3-[1-(aminomethyl)cyclohexyl]oxolan-3-yl}carbamate
  • tert-butyl N-{3-[(pyrrolidin-2-yl)methyl]oxolan-3-yl}carbamate
  • tert-butyl N-{5-[(1S)-3-amino-1-hydroxypropyl]pyrimidin-2-yl}carbamate
  • tert-butyl N-[3-amino-2-(4-acetamidophenyl)-2-methylpropyl]carbamate
  • Tert-butyl 3-(1-cyano-3-oxocyclobutyl)piperidine-1-carboxylate
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.